ArticleDiabetes2014
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
Article in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Pooled it
- Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.Nature communications · 2017Pooled it
- Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP.Diabetologia · 2014Pooled it
- Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity.Communications medicine · 2026Article
- Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities.Diabetologia · 2025Review
- Neuroimaging Genomics a Predictor of Major Depressive Disorder (MDD).Molecular neurobiology · 2024Review
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.Frontiers in endocrinology · 2023Article
- A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.Nature communications · 2022Article
- Article
- Limited extent and consequences of pancreatic SARS-CoV-2 infection.Cell reports · 2022Article
- Celebrities in the heart, strangers in the pancreatic beta cell: Voltage-gated potassium channels KActa physiologica (Oxford, England) · 2022Review
- Effect ofFrontiers in endocrinology · 2022Article
- Characterization of Exome Variants and Their Metabolic Impact in 6,716 American Indians from the Southwest US.American journal of human genetics · 2020Article
- Diabetes and cancer risk: A Mendelian randomization study.International journal of cancer · 2020Article
- Identifying the association between single nucleotide polymorphisms inInternational journal of medical sciences · 2020Observational
- Oncogene Delta/Notch-Like EGF-Related Receptor Promotes Cell Proliferation, Invasion, and Migration in Hepatocellular Carcinoma and Predicts a Poor Prognosis.Cancer biotherapy & radiopharmaceuticals · 2018Article
- Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.Annals of human genetics · 2018Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
Abstract
Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM in American Indians. Participants were selected from a longitudinal study conducted in Pima Indians and included 278 cases with diabetes with onset before 25 years of age, 295 nondiabetic controls ≥45 years of age, and 267 siblings of cases or controls. Individuals were genotyped on a ∼1M single nucleotide polymorphism (SNP) array, resulting in 453,654 SNPs with minor allele frequency >0.05. SNPs were analyzed for association in cases and controls, and a family-based association test was conducted. Tag SNPs (n = 311) were selected for 499 SNPs associated with diabetes (P < 0.0005 in case-control analyses or P < 0.0003 in family-based analyses), and these SNPs were genotyped in up to 6,834 additional Pima Indians to assess replication. Rs1861612 in DNER was associated with T2DM (odds ratio = 1.29 per copy of the T allele; P = 6.6 × 10(-8), which represents genome-wide significance accounting for the number of effectively independent SNPs analyzed). Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.