ArticleProceedings of the National Academy of Sciences of the United States of America2013
Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Functional Characterization of Tret1-like Gene and Its Critical Role in Regulating Growth inInternational journal of molecular sciences · 2026Article
- An Integrated Morphometric-Molecular Framework for Characterization of Developmental Stages in the Safflower AphidInternational journal of molecular sciences · 2026Article
- Ancient inversion polymorphisms are locally adaptive in a widespread butterfly species.Science advances · 2026Article
- Parallel expansion of trehalose transporter genes integrates intestinal energy metabolism with developmental growth in lepidopteran insects.Molecular biology and evolution · 2026Article
- Lipid Metabolism in Relation to Carbohydrate Metabolism.Advances in experimental medicine and biology · 2026Review
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus type 2 replication.PLoS pathogens · 2025Article
- Understanding the role of trehalose in interactions betweenFrontiers in cellular and infection microbiology · 2025Review
- Thermal acclimation uncovers a simple genetic basis of adaptation to high temperature in a cosmopolitan pest.iScience · 2024Article
- Protective roles of highly conserved motif 1 in tardigrade cytosolic-abundant heat soluble protein in extreme environments.Protein science : a publication of the Protein Society · 2024Article
- Article
- Genomic advances in the study of the mosquito vector during avian malaria infection.Parasitology · 2023Review
- Roles of Virtual Screening and Molecular Dynamics Simulations in Discovering and Understanding Antimalarial Drugs.International journal of molecular sciences · 2023Review
- Dehydration Alters Transcript Levels in the Mosquito Midgut, Likely Facilitating Rapid Rehydration following a Bloodmeal.Insects · 2023Article
- TargetingViruses · 2023Review
- Neuromodulation and differential learning across mosquito species.Proceedings. Biological sciences · 2023Article
- Article
- Article
- Trehalose provisioning inBiology letters · 2022Article
- Anopheles coluzzii stearoyl-CoA desaturase is essential for adult female survival and reproduction upon blood feeding.PLoS pathogens · 2021Article
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5 authors.
Funding
Abstract
Anopheles gambiae is a major vector mosquito for Plasmodium falciparum, the deadly pathogen causing most human malaria in sub-Saharan Africa. Synthesized in the fat body, trehalose is the predominant sugar in mosquito hemolymph. It not only provides energy but also protects the mosquito against desiccation and heat stresses. Trehalose enters the mosquito hemolymph by the trehalose transporter AgTreT1. In adult female A. gambiae, AgTreT1 is predominantly expressed in the fat body. We found that AgTreT1 expression is induced by environmental stresses such as low humidity or elevated temperature. AgTreT1 RNA silencing reduces the hemolymph trehalose concentration by 40%, and the mosquitoes succumb sooner after exposure to desiccation or heat. After an infectious blood meal, AgTreT1 RNA silencing reduces the number of P. falciparum oocysts in the mosquito midgut by over 70% compared with mock-injected mosquitoes. These data reveal important roles for AgTreT1 in stress adaptation and malaria pathogen development in a major vector mosquito. Thus, AgTreT1 may be a potential target for malaria vector control.
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