ArticleProceedings of the National Academy of Sciences of the United States of America2013
Cellular organization of cortical barrel columns is whisker-specific.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 103 citations in OpenAlex.
- Trends in neuroprosthetic technologies to restore sensations.Biomedical engineering letters · 2026Review
- Whisker stimulation reinforces a resting-state network in the barrel cortex: Nested oscillations and avalanches.PLoS computational biology · 2026Article
- Experimental evaluation of an integrated focused ultrasound and electroencephalography approach for developing activation-informed neuroimaging.NeuroImage · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.Nature communications · 2025Article
- Interdigitating Modules for Visual Processing During Locomotion and Rest in Mouse V1.bioRxiv : the preprint server for biology · 2025Article
- Three-dimensional architecture and linearized mapping of vibrissa follicle afferents.Nature communications · 2025Article
- Sparse connectivity enables efficient information processing in cortex-like artificial neural networks.Frontiers in neural circuits · 2025Article
- A layered microcircuit model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Sleep waves in a large-scale corticothalamic model constrained by activities intrinsic to neocortical networks and single thalamic neurons.CNS neuroscience & therapeutics · 2024Article
- Development of ocular dominance columns across rodents and other species: revisiting the concept of critical period plasticity.Frontiers in neural circuits · 2024Review
- Cell density quantification of high resolution Nissl images of the juvenile rat brain.Frontiers in neuroanatomy · 2024Article
- Simulation-based inference for efficient identification of generative models in computational connectomics.PLoS computational biology · 2023Article
- The 3D Structural Architecture of the Human Hand Area Is Nontopographic.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Modelling novelty detection in the thalamocortical loop.PLoS computational biology · 2023Article
- Layer-dependent stability of intracortical recordings and neuronal cell loss.Frontiers in neuroscience · 2023Article
- Cortical Representation of Touch in Silico.Neuroinformatics · 2022Article
- The impact of neuron morphology on cortical network architecture.Cell reports · 2022Article
- The Long-Term Stability of Intracortical Microstimulation and the Foreign Body Response Are Layer Dependent.Frontiers in neuroscience · 2022Article
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6 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The cellular organization of the cortex is of fundamental importance for elucidating the structural principles that underlie its functions. It has been suggested that reconstructing the structure and synaptic wiring of the elementary functional building block of mammalian cortices, the cortical column, might suffice to reverse engineer and simulate the functions of entire cortices. In the vibrissal area of rodent somatosensory cortex, whisker-related "barrel" columns have been referred to as potential cytoarchitectonic equivalents of functional cortical columns. Here, we investigated the structural stereotypy of cortical barrel columns by measuring the 3D neuronal composition of the entire vibrissal area in rat somatosensory cortex and thalamus. We found that the number of neurons per cortical barrel column and thalamic "barreloid" varied substantially within individual animals, increasing by ∼2.5-fold from dorsal to ventral whiskers. As a result, the ratio between whisker-specific thalamic and cortical neurons was remarkably constant. Thus, we hypothesize that the cellular architecture of sensory cortices reflects the degree of similarity in sensory input and not columnar and/or cortical uniformity principles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.