ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2014
Defining high risk: cost-effectiveness of extended-duration thromboprophylaxis following major oncologic abdominal surgery.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Role of Post-discharge Venous Thromboembolism Prophylaxis after Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Risk adjusted venous thromboembolism prophylaxis following pancreatic surgery.Journal of thrombosis and thrombolysis · 2023Article
- Cost-effectiveness of Venous Thromboembolism Prophylaxis After Hospitalization in Patients With Inflammatory Bowel Disease.Inflammatory bowel diseases · 2022Article
- Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Risk factors for venous thromboembolism after vascular surgery and implications for chemoprophylaxis strategies.Journal of vascular surgery. Venous and lymphatic disorders · 2022Article
- Venous thromboembolism in benign esophageal surgery patients: potential cost effectiveness of Caprini risk stratification.Surgical endoscopy · 2022Article
- Development and validation of a risk calculator for post-discharge venous thromboembolism following hepatectomy for malignancy.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2021Article
- A postdischarge venous thromboembolism risk calculator for inflammatory bowel disease surgery.Surgery · 2021Article
- Post-discharge venous thromboembolism after pancreatectomy for malignancy: Predicting risk based on preoperative, intraoperative, and postoperative factors.Journal of surgical oncology · 2020Article
- Population-Based Analysis of Adherence to Postdischarge Extended Venous Thromboembolism Prophylaxis After Colorectal Resection.Diseases of the colon and rectum · 2020Article
- Justifying Total Costs of Extended Venothromboembolism Prophylaxis After Colorectal Cancer Surgery.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- A Caprini Risk Score-Based Cost-Effectiveness Analysis of Enoxaparin for the Thromboprophylaxis of Patients After Nonorthopedic Surgery in a Chinese Healthcare Setting.Clinical drug investigation · 2020Article
- Cost-Benefit Limitations of Extended, Outpatient Venous Thromboembolism Prophylaxis Following Surgery for Crohn's Disease.Diseases of the colon and rectum · 2019Article
- Extended venous thromboembolism prophylaxis after abdominopelvic cancer surgery: a retrospective review.Current oncology (Toronto, Ont.) · 2019Article
- Risk factors for post-discharge venous thromboembolism in patients undergoing colorectal resection: a NSQIP analysis.Techniques in coloproctology · 2018Article
- Extended venous thromboembolism prophylaxis after colorectal cancer surgery: the current state of the evidence.Journal of thrombosis and thrombolysis · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeExtended-duration thromboprophylaxis (EDTPPX) is the practice of prescribing antithrombotic therapy for 21 days after discharge, commonly used in surgical patients who are at high risk for venothromboembolism (VTE). While guidelines recommend EDTPPX, criteria are vague due to a paucity of data. The criteria can be further informed by cost-effectiveness thresholds. This study sought to determine the VTE incidence threshold for the cost-effectiveness of EDTPPX compared to inpatient prophylaxis.
methodsA decision tree was used to compare EDTPPX for 21 days after discharge to 7 days of inpatient prophylaxis with base case assumptions based on an abdominal oncologic resection without complications in an otherwise healthy individual. Willingness to pay was set at $50,000/quality-adjusted life year (QALY). Sensitivity analyses were performed to assess uncertainty within the model, with particular interest in the threshold for cost-effectiveness based on VTE incidence.
resultsEDTPPX was the dominant strategy when VTE probability exceeds 2.39 %. Given a willingness to pay threshold of $50,000/QALY, EDTPPX was the preferred strategy when VTE incidence exceeded 1.22 and 0.88 % when using brand name or generic medication costs, respectively.
conclusionsEDTPPX should be recommended whenever VTE incidence exceeds 2.39 %. When post-discharge estimated VTE risk is 0.88-2.39 %, patient preferences about self-injections and medication costs should be considered.
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