Evidence map›Paper›PMID 24101445›Full record

ArticleMolecular and cellular biochemistry2014

IFN-γ (+874) and not TNF-α (-308) is associated with HBV-HCC risk in India.

Roli Saxena, Yogesh Kumar Chawla, Indu Verma, Jyotdeep Kaur

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Interferon-γ +874A/T polymorphism and hepatocellular carcinoma risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Polymorphism of IFN-γ (+874 T/A) in Syrian patients with chronic hepatitis B.Gastroenterology and hepatology from bed to bench · 2017
    Article
  12. Review
  13. Review
  14. Interferon-γ polymorphism and hepatocellular carcinoma susceptibility: a meta analysis.International journal of clinical and experimental medicine · 2015
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Roli SaxenaDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India.
Yogesh Kumar Chawla
Indu Verma
Jyotdeep Kaur
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor necrosis factor (TNF)-α and interferon (IFN)-γ, the pro-inflammatory Th1 cytokines are the indispensable coordinators of the inflammatory responses involved in hepatitis B virus (HBV) pathogenesis. This study attempted to evaluate any possible association among TNF-α (-308G>A) and IFN-γ (+874T/A) genotypes, the spontaneous blood and mRNA levels and expression of their major signal transducers, namely STAT1 and NF-кB with hepatitis B virus-induced hepatocellular carcinoma (HCC) susceptibility in India. For this, 398 subjects (146 controls, 68 inactive-HBV-carriers, 64 chronic-active HBV patients, 61 HBV-cirrhotics, and 59 HBV-HCC subjects) were enrolled. Polymerase chain reaction-restriction fragment length polymorphism, allele-specific PCR, enzyme-linked immunosorbent assay, reverse transcriptase-PCR, and Western blot analysis were done for assessing polymorphism, blood levels, mRNA expression, and protein expression of signal transducers, respectively, of TNF-α and IFN-γ. The study revealed no significant association of TNF-α (-308) GA genotype, while a significant negative association of IFN-γ (+874) TA and AA genotypes, in HBV-HCC risk. Moreover, blood levels of TNF-α were significantly elevated as disease progresses to HCC, while IFN-γ levels were raised in HCC patients only. Besides, IFN-γ mRNA levels were significantly elevated in cirrhotics, with no change observed in TNF-α transcript levels. Moreover, NF-кB expression also consistently increased during HCC progression. These observations suggest a vital negative association of IFN-γ (+874) with HBV-HCC risk, with no significant association evident in TNF-α (-308). However, the TNF-α and IFN-γ levels markedly increased in HCC development.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticCarcinoma, HepatocellularEnzyme-Linked Immunosorbent AssayGene Expression Regulation, NeoplasticGenetic Association StudiesHepatitis B virusHeterozygoteHumansIndiaInterferon-gammaLiver NeoplasmsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthRisk FactorsRNA, MessengerInterferon-gammaRNA, MessengerSTAT1 protein, humanSTAT1 Transcription FactorTranscription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID24101445
OpenAlexW1995208752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.