ArticlePflugers Archiv : European journal of physiology2014
Enteric sensory neurons communicate with interstitial cells of Cajal to affect pacemaker activity in the small intestine.
Article in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- International Forum on Visceral Myopathy 2024: Advances in the Knowledge of the Disease.Neurogastroenterology and motility · 2026Review
- Article
- Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model.Journal of neural engineering · 2024Article
- The enteric nervous system.Physiological reviews · 2023Review
- Studying Murine Small Bowel Mechanosensing of Luminal Particulates.Journal of visualized experiments : JoVE · 2022Article
- Cholesterol gallstones: Focusing on the role of interstitial Cajal-like cells.World journal of clinical cases · 2021Review
- Telocytes in the human sinoatrial node.Journal of cellular and molecular medicine · 2018Article
- Effects of Synbiotic2000™ Forte on the Intestinal Motility and Interstitial Cells of Cajal in TBI Mouse Model.Probiotics and antimicrobial proteins · 2017Article
- Slow Wave Activity and Modulations in Mouse Jejunum Myenteric Plexus In Situ.Journal of neurogastroenterology and motility · 2017Article
- Interdependency between mechanical parameters and afferent nerve discharge in remodeled diabetic Goto-Kakizaki rat intestine.Clinical and experimental gastroenterology · 2017Article
- Antibiotic Driven Changes in Gut Motility Suggest Direct Modulation of Enteric Nervous System.Frontiers in neuroscience · 2017Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Epigenetic aspects of telocytes/cordocytes: jacks of all trades, masters of most.Frontiers in cellular neuroscience · 2014Article
- The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach.Frontiers in molecular neuroscience · 2014Article
- Interstitial cells of Cajal: update on basic and clinical science.Current gastroenterology reports · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Enteric sensory neurons (the AH neurons) play a role in control of gastrointestinal motor activity; AH neuron activation has been proposed to change propulsion into segmentation. We sought to find a mechanism underlying this phenomenon. We formulated the hypothesis that AH neurons increase local ICC-MP (interstitial cells of Cajal associated with the myenteric plexus) pacemaker frequency to disrupt peristalsis and promote absorption. To that end, we sought structural and physiological evidence for communication between ICC-MP and AH neurons. We designed experiments that allowed us to simultaneously activate AH neurons and observe changes in ICC calcium transients that underlie its pacemaker activity. Neurobiotin injection in AH neurons together with ICC immunohistochemistry proved the presence of multiple contacts between AH neuron varicosities and the cell bodies and processes of ICC-MP. Generating action potential activity in AH neurons led to increase in the frequency and amplitude of calcium transients underlying pacemaker activity in ICC. When no rhythmicity was seen, rhythmic calcium transients were evoked in ICC. As a control, we stimulated nitrergic S neurons, which led to reduction in ICC calcium transients. Hence, we report here the first demonstration of communication between AH neurons and ICC. The following hypothesis can now be formulated: AH neuron activation can disrupt peristalsis directed by ICC-MP slow wave activity, through initiation of a local pacemaker by increasing ICC pacemaker frequency through increasing the frequency of ICC calcium transients. Evoking new pacemakers distal to the proximal lead pacemaker will initiate both retrograde and antegrade propulsion causing back and forth movements that may disrupt peristalsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.