ArticleEuropean radiology2014
Contrast-enhanced MRI compared with the physical examination in the evaluation of disease activity in juvenile idiopathic arthritis.
Article in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- 5.0-T magnetic resonance imaging and contrast-enhanced magnetic resonance angiography for the evaluation of juvenile idiopathic arthritis.Pediatric radiology · 2026Article
- From Hands to Imaging: The Emerging Role of Musculoskeletal Ultrasonography in Juvenile Idiopathic Arthritis Disease Activity Assessment.International journal of rheumatic diseases · 2026Article
- Temporo-mandibular joint alterations in juvenile idiopathic arthritis and young-onset inflammatory arthropathies: a magnetic resonance imaging study with ultrasound comparison.Pediatric rheumatology online journal · 2026Article
- Detection of inflammation by whole-body MRI in young people with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2024Article
- Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?Pediatric radiology · 2024Article
- The reliability of Juvenile Arthritis Magnetic Resonance Imaging Scoring system in the evaluation of the shoulder joint in juvenile idiopathic arthritis.Archives of rheumatology · 2022Article
- Intravoxel incoherent motion (IVIM) MRI in pediatric patients with synovitis of the knee joint: a prospective pilot study.Pediatric rheumatology online journal · 2022Article
- Physical Examination Tool for Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Pilot Diagnostic Accuracy Study.International journal of environmental research and public health · 2022Article
- Juvenile Idiopathic Arthritis: A Review of Novel Diagnostic and Monitoring Technologies.Healthcare (Basel, Switzerland) · 2021Review
- Magnetic resonance imaging findings in the sternoclavicular joint in juvenile idiopathic arthritis and comparison with clinical examination.Clinical rheumatology · 2021Article
- Diagnostic value of diffusion-weighted MRI for imaging synovitis in pediatric patients with inflammatory conditions of the knee joint.World journal of pediatrics : WJP · 2020Article
- Can quantitative MRI be used in the clinical setting to quantify the impact of intra-articular glucocorticoid injection on synovial disease activity in juvenile idiopathic arthritis?Pediatric rheumatology online journal · 2019Article
- Imaging of the knee in juvenile idiopathic arthritis.Pediatric radiology · 2018Review
- Contrast-enhanced MRI findings of the knee in healthy children; establishing normal values.European radiology · 2018Article
- Juvenile idiopathic arthritis: magnetic resonance imaging of the clinically unaffected knee.Pediatric radiology · 2018Article
- Physical Examination Tools Used to Identify Swollen and Tender Lower Limb Joints in Juvenile Idiopathic Arthritis: A Scoping Review.Arthritis · 2018Article
- Readout-segmented multi-shot diffusion-weighted MRI of the knee joint in patients with juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2017Article
- Intravoxel incoherent motion magnetic resonance imaging of the knee joint in children with juvenile idiopathic arthritis.Pediatric radiology · 2017Article
- Attitudes and Approaches for Withdrawing Drugs for Children with Clinically Inactive Nonsystemic JIA: A Survey of the Childhood Arthritis and Rheumatology Research Alliance.The Journal of rheumatology · 2017Article
- [Imaging options in pediatric rheumatology].Zeitschrift fur Rheumatologie · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the value of magnetic resonance imaging (MRI) in discriminating between active and inactive juvenile idiopathic arthritis (JIA) patients and to compare physical examination outcomes with MRI outcomes in the assessment of disease status in JIA patients.
methodsConsecutive JIA patients with knee involvement were prospectively studied using an open-bore MRI. Imaging findings from 146 JIA patients were analysed (59.6% female; mean age, 12.9 years). Patients were classified as clinically active or inactive. MRI features were evaluated using the JAMRIS system, comprising validated scores for synovial hypertrophy, bone marrow oedema, cartilage lesions and bone erosions.
resultsInter-reader reliability was good for all MRI features (intra-class correlation coefficient [ICC] = 0.87-0.94). No differences were found between the two groups regarding MRI scores of bone marrow oedema, cartilage lesions or bone erosions. Synovial hypertrophy scores differed significantly between groups (P = 0.016). Nonetheless, synovial hypertrophy was also present in 14 JIA patients (35.9%) with clinically inactive disease. Of JIA patients considered clinically active, 48.6% showed no signs of MRI-based synovitis.
conclusionsMRI can discriminate between clinically active and inactive JIA patients. However, physical examination is neither very sensitive nor specific in evaluating JIA disease activity compared with MRI. Subclinical synovitis was present in >35% of presumed clinically inactive patients. KEY POINTS: • MRI is sensitive for evaluating juvenile idiopathic arthritis (JIA) disease activity. • Contrast-enhanced MRI can distinguish clinically active and inactive JIA patients. • Subclinical synovitis is present in 35.9 % of presumed clinically inactive patients. • Physical examination is neither sensitive nor specific in evaluating JIA disease activity.
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