ArticlePsychopharmacology2014
Synergistic interaction between caloric restriction and amphetamine in food-unrelated approach behavior of rats.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.Progress in neurobiology · 2022Article
- Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice.Nature communications · 2021Article
- Genome-scale metabolic model of the rat liver predicts effects of diet restriction.Scientific reports · 2019Article
- Enhancement of a visual reinforcer by D-amphetamine and nicotine in adult rats: relation to habituation and food restriction.Psychopharmacology · 2018Article
- Interaction of chronic food restriction and methylphenidate in sensation seeking of rats.Psychopharmacology · 2017Article
- Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors.Psychopharmacology · 2016Article
- Effect of yohimbine on reinstatement of operant responding in rats is dependent on cue contingency but not food reward history.Addiction biology · 2015Article
- Similar roles of substantia nigra and ventral tegmental dopamine neurons in reward and aversion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Phasic excitation of ventral tegmental dopamine neurons potentiates the initiation of conditioned approach behavior: parametric and reinforcement-schedule analyses.Frontiers in behavioral neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
rationaleApproach behavior is regulated by the brain integrating information about environment and body state. Psychoactive drugs interact with this process.
objectivesWe examined the extent to which caloric (i.e., food) restriction, amphetamine (AMPH) and lithium interact in potentiating locomotor activity and responding reinforced by visual stimulus (VS), a reward unrelated to energy homeostasis.
methodsRats either had ad libitum access to food or received daily rations that maintained 85-90 % of their original body weights. Leverpressing turned on a cue light for 1 s and turned off house light for 5 s. AMPH and lithium were administered through intraperitoneal injections and diet, respectively.
resultsFood restriction or AMPH (1 mg/kg) alone had little effect on VS-reinforced responding; however, the combination of the two conditions markedly potentiated VS-reinforced responding (fourfold). Food restriction lasting 7 days or longer was needed to augment AMPH's effect on VS-reinforced responding. AMPH (0.3-3 mg/kg) potentiated locomotor activity similarly between food-restricted and ad libitum groups. Repeated injections of AMPH-sensitized locomotor activity, but not VS-reinforced responding. In addition, while chronic lithium treatments (0.2 % lithium carbonate chow) reduced VS-reinforced responding, chronic lithium further augmented AMPH-potentiated VS-reinforced responding.
conclusionsFood restriction interacts with psychoactive drugs to potentiate goal-directed responding unrelated to food seeking in a much more powerful manner than previously thought. The novel finding that lithium can augment a psychostimulant effect of AMPH suggests caution when combining lithium and psychostimulant drugs in clinical settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.