ArticleObesity surgery2014
Changes in intestinal permeability after Roux-en-Y gastric bypass.
Article in Obesity surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contribution of Malabsorption to Weight Loss After Roux-en-Y Gastric Bypass: a Systematic Review.Obesity surgery · 2017Pooled it
- Impact of Laparoscopic Sleeve Gastrectomy on Gut Permeability in Morbidly Obese Subjects.Obesity surgery · 2019Trial
- Comparison of the Effectiveness of Single Anastomosis Sleeve Ileal Bypass and Roux-en-Y Gastric Bypass in Obese Patients with Type 2 Diabetes.Obesity surgery · 2024Article
- Review
- Failed Roux-en-Y Gastric Bypass-Long-Term Results of Distalization with Total Alimentary Limb Length of 250 or 300 cm.Obesity surgery · 2023Article
- Optimized In Silico Modeling of Drug Absorption after Gastric Bypass: The Case of Metformin.Pharmaceutics · 2021Article
- PBPK modeling of CYP3A and P-gp substrates to predict drug-drug interactions in patients undergoing Roux-en-Y gastric bypass surgery.Journal of pharmacokinetics and pharmacodynamics · 2020Article
- Intestinal barrier function in morbid obesity: results of a prospective study on the effect of sleeve gastrectomy.International journal of obesity (2005) · 2020Article
- Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice.Obesity surgery · 2017Article
- Duodenojejunal Bypass Leads to Altered Gut Microbiota and Strengthened Epithelial Barriers in Rats.Obesity surgery · 2016Article
- Outcome of intestinal failure after bariatric surgery: experience from a national UK referral centre.European journal of clinical nutrition · 2016Article
- The gut microbiome, diet, and links to cardiometabolic and chronic disorders.Nature reviews. Nephrology · 2016Review
- The effects of gastrointestinal surgery on gut microbiota: potential contribution to improved insulin sensitivity.Current atherosclerosis reports · 2014Review
- Non-alcoholic fatty liver disease, diet and gut microbiota.EXCLI journal · 2014Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) interferes considerably with the anatomy and physiology of the gastrointestinal tract. The study of intestinal permeability can provide important information regarding changes in the structure and function of the mucosal barrier after the procedure.
methodsThe urinary excretion rates of lactulose and mannitol after oral intake of both substances were evaluated. We also evaluated the lactulose/mannitol excretion ratio. Tests were performed during the preoperative period (T0), at the first postoperative month (T1), and at the sixth postoperative month (T6).
resultsThe study included 16 morbidly obese patients. The excretion rate of mannitol was significantly lower at T1 compared with T0 and T6 (p = 0.003). There was no significant difference in the excretion rates of lactulose or in the lactulose/mannitol ratio during the three periods. Six patients (37.5%) exhibited a considerable increase in the excretion rate of lactulose at T6 (4-73 times higher than the preoperative value), accompanied by proportional variations in the lactulose/mannitol ratio.
conclusionsThe significant increase in mannitol excretion rate from T1 to T6 most likely reflects the occurrence of intestinal adaptation (mucosal hyperplasia), which would tend to minimize the malabsorption of macronutrients. A subgroup of patients who undergo RYGB exhibit pronounced increase in their intestinal permeability (assessed by the lactulose/mannitol ratio and the lactulose excretion rate) at T6.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.