ArticleWorld journal of surgery2013
Postoperative chyle leak after major pancreatic resections in patients who receive enteral feed: risk factors and management options.
Article in World journal of surgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Incidence and risk factors for Chyle leak after pancreatic surgery for cancer: A comprehensive systematic review.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2022Pooled it
- Medium-Chain Triglyceride (MCT) Content of Adult Enteral Tube Feeding Formulas and Clinical Outcomes. A Systematic Review.Frontiers in nutrition · 2021Pooled it
- The postoperative drain lymphocyte count as a novel predictor of chyle leakage after pancreatic surgery.Surgery today · 2026Article
- Operative management for refractory chyle leakage after pancreatectomy: A case report and literature review.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Neoadjuvant Treatment is a Risk Factor for Clinically Relevant Chyle Leak (ISGPS Grade B/C) After Pancreatic Cancer Resection: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- Article
- Dietary interventionsWorld journal of transplantation · 2025Article
- Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach.World journal of clinical cases · 2025Article
- Lymph node Yield in Apical Tissue During Triangle Operation While Doing Whipples Operation: An Observational Study.JNMA; journal of the Nepal Medical Association · 2025Observational
- Role of Lipiodol® lymphangiography in the diagnosis and management of post-operative chylous ascites.Frontiers in radiology · 2025Article
- Venous resection increases risk of chyle leak after total pancreatectomy for pancreatic tumors.World journal of surgical oncology · 2024Article
- The impact of lymphangiograpy on chyle leakage treatment duration after pancreatic surgery.Surgery today · 2024Article
- The application of a medium-chain fatty diet and enteral nutrition in post-operative chylous leakage: analysis of 63 patients.Frontiers in nutrition · 2023Article
- Risk factors of chylous ascites and its relationship with long-term prognosis in laparoscopic D3 lymphadenectomy for right colon cancer.Langenbeck's archives of surgery · 2022Article
- Hepatic lymphorrhea following pancreaticoduodenectomy: Preliminary diagnosis and treatment experience from case series of four patients.Annals of medicine and surgery (2012) · 2021Article
- Oligomeric Formulas in Surgery: A Delphi and Consensus Study.Nutrients · 2021Article
- Successful minimal invasive treatment of chylous ascites following pancreaticoduodenectomy: A case report and review of literature.Annals of medicine and surgery (2012) · 2021Article
- Management of chylous ascites following pancreaticobiliary surgery.JGH open : an open access journal of gastroenterology and hepatology · 2019Article
- Classifying Enteral Nutrition: Tailored for Clinical Practice.Current gastroenterology reports · 2019Review
- Implementation and Evaluation of a Clinical Pathway for Pancreaticoduodenectomy Procedures: a Prospective Cohort Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChyle leak complicates 1.3-10.8 % of pancreatic resections. Universal use of parenteral nutrition following pancreatic resection may reduce the incidence of chyle leak. However, this denies the majority of patients who do not develop chyle leak the benefits of enteral nutrition (EN). The present study aimed to identify risk factors for chyle leak following pancreatic resection within a single institution where EN was used universally.
methodsAll patients who underwent pancreatic resection between January 2007 and December 2010 were identified retrospectively. The patients had been treated according to a common unit protocol of enteral feeding; those developing chyle leak were switched to a medium-chain triglyceride (MCT) regimen. Clinical progress and recovery after surgery was evaluated. Multivariate analysis was performed to identify factors associated with chyle leak.
resultsA total of 245 patients underwent major pancreatic resection (231 pancreatoduodenectomy, 14 total pancreatectomy). Chyle leak complicated 40 cases (16.3 %). After multivariate analysis, both extensive lymphadenectomy (P = 0.002) and postoperative portal/mesenteric venous thrombosis (PVT) (P = 0.009) were independently linked with a higher incidence of chyle leak. The development of chyle leak was not associated with poorer survival or prolonged duration of hospital stay. It was associated with a significantly increased duration of abdominal drainage and reduced likelihood of early hospital discharge (P = 0.026).
conclusionsUniversal use of enteral feeding is associated with a high rate of chyle leak following pancreatic resection. Patients undergoing extensive lymphadenectomy or those who develop PVT postoperatively are at increased risk. Development of chyle leak was not associated with additional morbidity or mortality following implementation of an MCT regimen. The implication is that reactive management of chyle leak with conversion to a MCT predominant diet is safe.
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