ReviewCurrent opinion in clinical nutrition and metabolic care2013
Amino acid transporters in the regulation of human skeletal muscle protein metabolism.
Review in Current opinion in clinical nutrition and metabolic care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Resistance training partially restores age-related differences in skeletal muscle amino acid transporters - secondary analysis from two randomized controlled trials.The journal of nutrition, health & aging · 2026Trial
- Casein Protein Processing Strongly Modulates Post-Prandial Plasma Amino Acid Responses In Vivo in Humans.Nutrients · 2020Trial
- Effects of Photoperiods on Growth Performance, Serum Biochemical Parameters, Slaughter Performance, Skeletal Development, and Meat Quality of Yellow-Feathered Broilers.Animals : an open access journal from MDPI · 2026Article
- The Influence of Acute Beta-Hydroxy Beta-Methylbutyrate (HMB) Ingestion on the Human Skeletal Muscle Transcriptome.Nutrients · 2026Article
- Treatment with L-type amino acid transporter 1 inhibitor JPH203 enhances protein synthesis in C2C12 myotubes.Scientific reports · 2025Article
- Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies.European journal of applied physiology · 2025Review
- Reconsidering the pre-eminence of dietary leucine and plasma leucinemia for predicting the stimulation of postprandial muscle protein synthesis rates.The American journal of clinical nutrition · 2024Article
- The skeletal muscle fiber periphery: A nexus of mTOR-related anabolism.Sports medicine and health science · 2023Review
- Genetically personalised organ-specific metabolic models in health and disease.Nature communications · 2022Article
- Article
- Protein Requirements for Master Athletes: Just Older Versions of Their Younger Selves.Sports medicine (Auckland, N.Z.) · 2021Review
- Amino Acid-Induced Impairment of Insulin Signaling and Involvement of G-Protein Coupling Receptor.Nutrients · 2021Review
- Article
- Gene regulation could be attributed to TCF3 and other key transcription factors in the muscle of pubertal heifers.Veterinary medicine and science · 2020Article
- Reduced NaThe Journal of physiology · 2020Article
- Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction.Journal of cachexia, sarcopenia and muscle · 2020Article
- Protein: what's on in research on clinical nutrition.European journal of clinical nutrition · 2018Review
- Article
- Efficacy and Safety of Leucine Supplementation in the Elderly.The Journal of nutrition · 2016Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewTo highlight recent research on amino acid sensing and signaling and the role of amino acid transporters in the regulation of human skeletal muscle protein metabolism. RECENT
findingsThe mechanisms that sense amino acid availability and activate mechanistic target of rapamycin complex 1 signaling and protein synthesis are emerging, with multiple new proteins and intracellular amino acid sensors recently identified. Amino acid transporters have a role in the delivery of amino acids to these intracellular sensors and new findings provide further support for amino acid transporters as possible extracellular amino acid sensors. There is growing evidence in human skeletal muscle that amino acid transporter expression is dynamic and responsive to various stimuli, indicating amino acid transporters may have a unique role in the regulation of human skeletal muscle adaptation. SUMMARY: There is a clear need to further examine the role of amino acid transporters in human skeletal muscle and their link to cellular amino acid sensing and signaling in the control of protein metabolism. A better understanding of amino acid transport and transporters will allow us to optimize nutritional strategies to accelerate muscle health and improve outcomes for clinical populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.