Evidence map›Paper›PMID 24100575›Full record

ArticleActa crystallographica. Section F, Structural biology and crystallization communications2013

Crystallization and preliminary structural characterization of the two actin isoforms of the malaria parasite.

Saligram Prabhakar Bhargav, Juha Vahokoski, Esa-Pekka Kumpula, Inari Kursula

Open access · bronzeAbstract read
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Article in Acta crystallographica. Section F, Structural biology and crystallization communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Saligram Prabhakar BhargavDepartment of Biochemistry, University of Oulu, PO Box 3000, 90014 Oulu, Finland.
Juha Vahokoski
Esa-Pekka Kumpula
Inari Kursula
University of Oulu · FIHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is a devastating disease caused by apicomplexan parasites of the genus Plasmodium that use a divergent actin-powered molecular motor for motility and invasion. Plasmodium actin differs from canonical actins in sequence, structure and function. Here, the purification, crystallization and secondary-structure analysis of the two Plasmodium actin isoforms are presented. The recombinant parasite actins were folded and could be purified to homogeneity. Plasmodium actins I and II were crystallized in complex with the gelsolin G1 domain; the crystals diffracted to resolutions of 1.19 and 2.2 Å and belonged to space groups P2₁2₁2₁ and P2₁, respectively, each with one complex in the asymmetric unit.

Indexed as

ActinsAmino Acid SequenceAnimalsChromatography, GelCircular DichroismCrystallizationCrystallography, X-RayMalariaMiceMolecular Sequence DataPlasmodium falciparumProtein IsoformsProtozoan ProteinsRecombinant ProteinsActinsProtein IsoformsProtozoan ProteinsRecombinant Proteinsactincircular-dichroism spectroscopymalariaPlasmodiumprotein–protein complex

Identifiers

PMID24100575
PMCPMC3792683
OpenAlexW2089590811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.