ArticleAntimicrobial agents and chemotherapy2013
Evaluation of the efficacies of Amphotericin B, Posaconazole, Voriconazole, and Anidulafungin in a murine disseminated infection by the emerging opportunistic Fungus Sarocladium (Acremonium) kiliense.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Morphological and genetic characterization of novelMicrobiology spectrum · 2026Article
- Three novel species ofMycoKeys · 2025Article
- Article
- The High Diversity and Variable Susceptibility of Clinically Relevant Acremonium-Like Species in China.Mycopathologia · 2019Article
- Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil.PLoS neglected tropical diseases · 2017Article
- Phylogeny of Sarocladium (Hypocreales).Persoonia · 2015Article
- In vitro evaluation of antifungal drug combinations against Sarocladium (Acremonium) kiliense, an opportunistic emergent fungus resistant to antifungal therapies.Antimicrobial agents and chemotherapy · 2014Article
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6 authors.
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Abstract
We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-d-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-d-glucan serum levels were equally reduced by all drugs evaluated.
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