ArticleBlood2013
BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors.
Article in Blood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development.Development, growth & differentiation · 2022Article
- Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System.Frontiers in cell and developmental biology · 2021Review
- CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- The pluripotency factor NANOG controls primitive hematopoiesis and directly regulatesThe EMBO journal · 2019Article
- Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function.BMC genomics · 2018Article
- Primitive erythrocytes are generated from hemogenic endothelial cells.Scientific reports · 2017Article
- Dissecting BMP signaling input into the gene regulatory networks driving specification of the blood stem cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.Development (Cambridge, England) · 2016Article
- Pias1 is essential for erythroid and vascular development in the mouse embryo.Developmental biology · 2016Article
- Lost in translation: pluripotent stem cell-derived hematopoiesis.EMBO molecular medicine · 2015Review
- Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2.EMBO reports · 2015Article
- A Molecular atlas of Xenopus respiratory system development.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Redox regulation of endothelial cell fate.Cellular and molecular life sciences : CMLS · 2014Article
- Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos.Developmental biology · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
The developmental relationship between the blood and endothelial cell (EC) lineages remains unclear. In the extra-embryonic blood islands of birds and mammals, ECs and blood cells are closely intermixed, and blood island precursor cells in the primitive streak express many of the same molecular markers, leading to the suggestion that both lineages arise from a common precursor, called the hemangioblast. Cells within the blood island of Xenopus also coexpress predifferentiation markers of the blood and EC lineages. However, using multiple assays, we find that precursor cells in the Xenopus blood island do not normally differentiate into ECs, suggesting that classic hemangioblasts are rare or nonexistent in Xenopus. What prevents these precursor cells from developing into mature ECs? We have found that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an EC fate. Furthermore, inhibition of the erythroid transcription pathway leads to endothelial differentiation. Our results indicate that bipotential endothelial/erythroid precursor cells do indeed exist in the Xenopus blood island, but BMP signaling normally acts to constrain EC fate. More generally, these results provide evidence that commitment to the erythroid lineage limits development of bipotential precursors toward an endothelial fate.
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