ArticleThe Journal of cell biology2013
Patronin mediates a switch from kinesin-13-dependent poleward flux to anaphase B spindle elongation.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Patronin facilitates neurite remodeling via epithelial-to-neuronal signaling.Cell communication and signaling : CCS · 2026Article
- Article
- Patronin regulates presynaptic microtubule organization and neuromuscular junction development iniScience · 2024Article
- Deciphering the roles of cell shape and Fat and Dachsous planar polarity in arranging theMolecular biology of the cell · 2023Article
- Kinesin-directed secretion of basement membrane proteins to a subdomain of the basolateral surface in Drosophila epithelial cells.Current biology : CB · 2022Article
- Symmetry breaking in the female germline cyst.Science (New York, N.Y.) · 2021Article
- Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.Cell death and differentiation · 2021Article
- Structural determinants of microtubule minus end preference in CAMSAP CKK domains.Nature communications · 2019Article
- The role of Patronin in Drosophila mitosis.BMC molecular and cell biology · 2019Article
- A homeostatic apical microtubule network shortens cells for epithelial folding via a basal polarity shift.Nature cell biology · 2018Article
- A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.Nature structural & molecular biology · 2017Article
- Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.Nature cell biology · 2017Article
- Anaphase B.Biology · 2016Review
- Patronin/Shot Cortical Foci Assemble the Noncentrosomal Microtubule Array that Specifies the Drosophila Anterior-Posterior Axis.Developmental cell · 2016Article
- CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Control of microtubule organization and dynamics: two ends in the limelight.Nature reviews. Molecular cell biology · 2015Review
- An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.Nature communications · 2015Article
- Emergent Properties of the Metaphase Spindle.Cold Spring Harbor perspectives in biology · 2015Review
- Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle.Nature communications · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Anaphase B spindle elongation contributes to chromosome segregation during Drosophila melanogaster embryo mitosis. We propose that this process is driven by a kinesin-5-generated interpolar microtubule (MT; ipMT) sliding filament mechanism that engages when poleward flux is turned off. In this paper, we present evidence that anaphase B is induced by the minus end-stabilizing protein patronin, which antagonizes the kinesin-13 depolymerase KLP10A at spindle poles, thereby switching off the depolymerization of the minus ends of outwardly sliding ipMTs to suppress flux. Although intact cortices, kinetochore MTs, and midzone augmentation are dispensable, this patronin-based change in ipMT minus-end dynamics is sufficient to induce the elongation of spindles capable of separating chromosomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.