ArticleScientific reports2013
Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Role of genetic mutations in folate-related enzyme genes on Male Infertility.Scientific reports · 2015Pooled it
- Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis.Scientific reports · 2014Pooled it
- Protein interacting with C-kinase 1 is correlated to prognosis and immune infiltrates of gastric cancer.Discover oncology · 2025Article
- The human EF1a promoter does not provide expression of the transgene in mice.Transgenic research · 2022Article
- Review
- MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation.Stem cell reports · 2020Article
- Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis.Cell reports · 2017Article
- Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality.Molecular medicine reports · 2016Article
- An efficient strategy for generation of transgenic mice by lentiviral transduction of male germline stem cells in vivo.Journal of animal science and biotechnology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein with high expression in brain, testis, pancreas and other neuroendocrine tissues. Male Pick1 knockout mice are completely infertile, with a phenotype resembling the human disease globozoospermia. Since PICK1 is expressed in both testis and neuroendocrine tissues, infertility of Pick1 knockout mice may be due to either impaired neuroendocrine function or abnormal spermatogenesis. To distinguish these two possibilities, we restored PICK1's expression in the testis by seminiferous tubule microinjection of PICK1-containing lentivirus. By examining the testis-specific Pick1 transgenic mice, we found that PICK1's expression in testis rescued the spermatogenic abnormalities and male infertility in Pick1 knockout mice. Our results indicate that the infertility is caused by the lack of PICK1 in the testis rather than in other organs. In addition, we found that seminiferous tubule microinjection of lentivirus has a strong preference to produce testis-specific transgenic mice.
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Registered trials
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