Evidence map›Paper›PMID 24100209›Full record

ArticleRNA biology2013

Trip to ER: MicroRNA-mediated translational repression in plants.

Xuan Ma, Xiaofeng Cao, Beixin Mo, Xuemei Chen

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Genes involved in miRNA biogenesis affect meiosis and fertility.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018
    Review
  4. Article
  5. Article
  6. Frontiers in plant science · 2017
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xuan MaShenzhen Key Laboratory of Microbial Genetic Engineering; College of Life Sciences; Shenzhen University; Shenzhen, P.R. China; Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, P.R. China.
Xiaofeng CaoInstitute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, P.R. China.
Beixin MoShenzhen Key Laboratory of Microbial Genetic Engineering; College of Life Sciences; Shenzhen University; Shenzhen, P.R. China.
Xuemei ChenDepartment of Botany and Plant Sciences; Institute of Integrative Genome Biology; University of California; Riverside, CA USA; Howard Hughes Medical Institute; University of California; Riverside, CA USA.
Shenzhen University · CNInstitute of Genetics and Developmental Biology · CNUniversity of California System · US

Funding

Regulation of APETALA2 in flower development in ArabidopsisR01GM061146 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI CHEN, MENG · 2000 to 2022
$6.5M
Howard Hughes Medical InstituteNIGMS NIH HHS GM61146NIGMS NIH HHS R01 GM061146
6 · The paper itself

Abstract

miRNAs elicit gene silencing at the post-transcriptional level by several modes of action: translational repression, mRNA decay, and mRNA cleavage. Studies in animals have suggested that translational repression occurs at early steps of translation initiation, which can be followed by deadenylation and mRNA decay. Plant miRNAs were originally thought to solely participate in mRNA cleavage, but increasing evidence has indicated that they are also commonly involved in translational inhibition. Here we discuss recent findings on miRNA-mediated translational repression in plants. The identification of AMP1 in Arabidopsis as a protein required for the translational repression but not the mRNA cleavage activity of miRNAs links miRNA-based translational repression to the endoplasmic reticulum (ER). Future work is required to further elucidate the miRNA machinery on the ER.

Indexed as

Protein BiosynthesisAnimalsArabidopsisEndoplasmic ReticulumGene SilencingLipid MetabolismMicroRNAsMicrotubulesRNA, MessengerRNA, PlantRNA StabilityMicroRNAsRNA, MessengerRNA, Plantargonauteendoplasmic reticulum (ER)miRNAmRNA cleavagemRNA decaytranslational repression

Identifiers

PMID24100209
PMCPMC3866237
OpenAlexW1975034172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.