Evidence map›Paper›PMID 24100022›Full record

ArticleExperimental neurology2013

Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.

Cara L Wellman, Marguerite Camp, V Morgan Jones, Kathryn P MacPherson, Jessica Ihne, Paul Fitzgerald, Mouna Maroun, Emily Drabant, Ryan Bogdan, Ahmad R Hariri and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  7. The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Review
  8. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  9. Review
  10. Article
  11. Article
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  13. Review
  14. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Cara L WellmanDepartment of Psychological and Brain Sciences, Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN, USA. Electronic address: wellmanc@indiana.edu.
Marguerite Camp
V Morgan Jones
Kathryn P MacPherson
Jessica Ihne
Paul Fitzgerald
Mouna Maroun
Emily Drabant
Ryan Bogdan
Ahmad R Hariri
Andrew Holmes
National Institutes of Health · USDuke University · USIndiana University Bloomington · US23andMe (United States) · USUniversity of Haifa · IL

Funding

Mouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7M
Mouse models of the early life origins of stress disordeZ01AA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2004 to 2008
$1.9M
Intramural NIH HHS Z01 AA000411
6 · The paper itself

Abstract

Serotonin is critical for shaping the development of neural circuits regulating emotion. Pet-1 (FEV-1) is an ETS-domain transcription factor essential for differentiation and forebrain targeting of serotonin neurons. Constitutive Pet-1 knockout (KO) causes major loss of serotonin neurons and forebrain serotonin availability, and behavioral abnormalities. We phenotyped Pet-1 KO mice for fear conditioning and extinction, and on a battery of assays for anxiety- and depression-related behaviors. Morphology of Golgi-stained neurons in basolateral amygdala (BLA) and prelimbic cortex was examined. Using human imaging genetics, a common variant (rs860573) in the PET-1 (FEV) gene was tested for effects on threat-related amygdala reactivity and psychopathology in 88 Asian-ancestry subjects. Pet-1 KO mice exhibited increased acquisition and expression of fear, and elevated fear recovery following extinction, relative to wild-type (WT). BLA dendrites of Pet-1 KO mice were significantly longer than in WT. Human PET-1 variation associated with differences in amygdala threat processing and psychopathology. This novel evidence for the role of Pet-1 in fear processing and dendritic organization of amygdala neurons and in human amygdala threat processing extends a growing literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation via effects on structure and function of underlying corticolimbic circuitry.

Indexed as

AmygdalaAnimalsAnxiety DisordersConditioning, ClassicalDendritesDNA-Binding ProteinsEmotionsExtinction, PsychologicalFearFemaleGenetic Predisposition to DiseaseGenotypeHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleDNA-Binding ProteinsFEV protein, humanFev protein, mouseNuclear ProteinsTranscription Factors5-HTTbasolateral amygdalaBasolateral amygdalaBLAethanolEtOHFear conditioningFEVknockoutKOMedial prefrontal cortexPet-1, FEVPheochromocytoma 12 etsPLposttraumatic stress disorderprelimbic cortexPTSDSerotoninthe serotonin transporterTph2tryptophan hydroxylase-2ventromedial prefrontal cortexvmPFC

Identifiers

PMID24100022
PMCPMC3932627
OpenAlexW2044256411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.