ArticleMolecular and cellular biology2013
Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells.
Article in Molecular and cellular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Role of microRNAs and their downstream target transcription factors in zebrafish thrombopoiesis.Scientific reports · 2023Article
- Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis.Research square · 2023Article
- Loss of IRF7 accelerates acute myeloid leukemia progression and induces VCAM1-VLA-4 mediated intracerebral invasion.Oncogene · 2022Article
- Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos.Nature communications · 2022Article
- Loss of TG-Interacting Factor 1 decreases survival in mouse models of myeloid leukaemia.Journal of cellular and molecular medicine · 2020Article
- Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension.Pulmonary circulation · 2019Article
- A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo.Stem cell research · 2018Article
- TGFβ induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/β-catenin signaling.Oncotarget · 2017Article
- miR-99 regulates normal and malignant hematopoietic stem cell self-renewal.The Journal of experimental medicine · 2017Article
- Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development.Cellular & molecular immunology · 2017Article
- Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.International journal of molecular sciences · 2017Article
- Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers.Stem cell research & therapy · 2016Article
- Bone Marrow-derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2016Article
- An integrated systems biology approach identifies positive cofactor 4 as a factor that increases reprogramming efficiency.Nucleic acids research · 2016Article
- TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Stem cells (Dayton, Ohio) · 2015Article
- Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation.Journal of thrombosis and haemostasis : JTH · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
TG-interacting factor 1 (TGIF1) is a transcriptional repressor that can modulate retinoic acid and transforming growth factor β signaling pathways. It is required for myeloid progenitor cell differentiation and survival, and mutations in the TGIF1 gene cause holoprosencephaly. Furthermore, we have previously observed that acute myelogenous leukemia (AML) patients with low TGIF1 levels had worse prognoses. Here, we explored the role of Tgif1 in murine hematopoietic stem cell (HSC) function. CFU assays showed that Tgif1(-/-) bone marrow cells produced more total colonies and had higher serial CFU potential. These effects were also observed in vivo, where Tgif1(-/-) bone marrow cells had higher repopulation potential in short- and long-term competitive repopulation assays than wild-type cells. Serial transplantation and replating studies showed that Tgif1(-/-) HSCs exhibited greater self-renewal and were less proliferative and more quiescent than wild-type cells, suggesting that Tgif1 is required for stem cells to enter the cell cycle. Furthermore, HSCs from Tgif1(+/-) mice had a phenotype similar to that of HSCs from Tgif1(-/-) mice, while bone marrow cells with overexpressing Tgif1 showed increased proliferation and lower survival in long-term transplant studies. Taken together, our data suggest that Tgif1 suppresses stem cell self-renewal and provide clues as to how reduced expression of TGIF1 may contribute to poor long-term survival in patients with AML.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.