ArticleDrug and alcohol dependence2013
C-reactive protein and substance use disorders in adolescence and early adulthood: a prospective analysis.
Article in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The impact of cannabis on immune checkpoint inhibitor therapy: a systematic review of immunomodulatory effects of cannabis in patients with and without cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Inflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Cardiovascular Health among U.S. Indigenous Peoples: A Holistic and Sex-Specific Systematic Review.Journal of evidence-based social work (2019)Pooled it
- Trial
- Interleukin-6 responses to acute stress are not altered in alcohol use disorder despite elevated baseline inflammation.Brain, behavior, & immunity - health · 2026Article
- Systemic Biomarker Alterations in Alcohol and Psychoactive Substance Users: A Cross-Sectional Study.Biomolecules · 2026Article
- Building social and structural connections for the prevention of opioid use among youth experiencing homelessness: study protocol for a randomized controlled trial.BMC public health · 2026Article
- The landscape of plasma proteomic links to human organ imaging.Nature communications · 2026Article
- Cytokine Networks in Alcohol Use Disorder: A Narrative Review Highlighting Research Gaps and Future Priorities.Medical sciences (Basel, Switzerland) · 2026Review
- VEXAS Syndrome and Substance Use Disorders: A Large-Scale, Propensity-Matched, Case-Control Analysis Revealing Immune-Mediated Comorbidities.International journal of dermatology · 2026Article
- The effect of neuroimmune signalling on drug addiction.Frontiers in pharmacology · 2026Review
- Investigating psychosocial factors and systemic inflammation using dried blood spots: a scoping review.Social psychiatry and psychiatric epidemiology · 2025Article
- Childhood allostatic load predicts cardiometabolic health in adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- High-intensity ethanol binge drinking accentuates bone damage in induced apical periodontitis in rats.Heliyon · 2024Article
- DNA methylation and gene expression of immune cell markers in adolescents with chronic cannabis use: an exploratory study.BMC psychiatry · 2024Article
- HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Alcohol and inflammation: Examining differences at the intersection of sexual identity and race/ethnicity.Alcohol (Fayetteville, N.Y.) · 2024Article
- Microglia in neuroimmunopharmacology and drug addiction.Molecular psychiatry · 2024Review
- Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Association between healthy lifestyle factors and health-related quality of life among Chinese adolescents: the moderating role of gender.Health and quality of life outcomes · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundDysregulated immune function and elevated inflammation markers are seen in adults with chronic diseases, including some psychiatric disorders, but evidence on inflammation in the case of drug abuse is conflicting.
objectiveTo test the concurrent and predictive relations between C-reactive protein (CRP) and use and abuse of alcohol, nicotine and cannabis in a longitudinal, population sample of adolescents and young adults, at the period of highest increase in drug use.
methodsData from the prospective population-based Great Smoky Mountains Study (N=1420) were used, covering children in the community assessed at ages 9-16, 19, and 21. Structured interviews were used to assess substance abuse symptoms and DSM-IV substance use disorders. Bloodspots were collected at each assessment and assayed for CRP.
resultsCRP levels were higher in the presence of nicotine, alcohol, and cannabis use and nicotine dependence. In prospective analyses, higher CRP levels predicted cannabis use and nicotine dependence, and nicotine use predicted higher CRP levels, once covariates were included in the models. Significant covariates were age, race (American Indian), and obesity.
conclusionsThe inter-relationship of CRP and substance abuse has implications for the later health risks associated with early drug and alcohol use and abuse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.