ArticleCancer letters2014
Identification of a mitotic death signature in cancer cell lines.
Article in Cancer letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways.The Journal of biological chemistry · 2022Article
- Article
- Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells.Journal of the Egyptian National Cancer Institute · 2021Article
- Mitotic checkpoint defects: en route to cancer and drug resistance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Review
- Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.Cell death & disease · 2019Article
- Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells.Cell research · 2018Article
- Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase.Cell cycle (Georgetown, Tex.) · 2018Article
- The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells.Scientific reports · 2017Article
- Small peptide substrates and high resolution peptide gels for the analysis of site-specific protein phosphorylation and dephosphorylation.Journal of biological methods · 2017Article
- Article
- Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword.Journal of experimental & clinical cancer research : CR · 2016Review
- Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells.Cancer research · 2016Article
- The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.The Journal of pharmacology and experimental therapeutics · 2015Article
- Targeting the Mitotic Catastrophe Signaling Pathway in Cancer.Mediators of inflammation · 2015Review
- Bcl-xL controls a switch between cell death modes during mitotic arrest.Cell death & disease · 2014Article
- SKI-178: A Multitargeted Inhibitor of Sphingosine Kinase and Microtubule Dynamics Demonstrating Therapeutic Efficacy in Acute Myeloid Leukemia Models.Cancer translational medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This study examined the molecular mechanism of action of anti-mitotic drugs. The hypothesis was tested that death in mitosis occurs through sustained mitotic arrest with robust Cdk1 signaling causing complete phosphorylation of Mcl-1 and Bcl-xL, and conversely, that mitotic slippage is associated with incomplete phosphorylation of Mcl-1/Bcl-xL. The results, obtained from studying six different cancer cell lines, strongly support the hypothesis and identify for the first time a unique molecular signature for mitotic death. The findings represent an important advance in understanding anti-mitotic drug action and provide insight into cancer cell susceptibility to such drugs which has important clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.