ArticleThe Journal of physiology2014
Modulation of stimulus-specific adaptation by GABA(A) receptor activation or blockade in the medial geniculate body of the anaesthetized rat.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 71 citations in OpenAlex.
- Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder.Translational psychiatry · 2023Trial
- Distinct millisecond-scale click-train patterns evoke discriminable behavioral and neural responses in humans and rats.PLoS biology · 2026Article
- Hierarchical Temporal Processing in the Primate Thalamocortical System: Insights from Nonlinguistic Structured Stimuli.Research (Washington, D.C.) · 2025Article
- Fast frequency modulation is encoded according to the listener expectations in the human subcortical auditory pathway.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Novelty detection in an auditory oddball task on freely moving rats.Communications biology · 2023Article
- Habituation, Adaptation and Prediction Processes in Neurodevelopmental Disorders: A Comprehensive Review.Brain sciences · 2023Review
- Adaptation in auditory processing.Physiological reviews · 2023Review
- Predictive encoding of pure tones and FM-sweeps in the human auditory cortex.Cerebral cortex communications · 2022Article
- Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging.Hearing research · 2021Review
- Adjudicating Between Local and Global Architectures of Predictive Processing in the Subcortical Auditory Pathway.Frontiers in neural circuits · 2021Review
- Article
- The role of adaptation in generating monotonic rate codes in auditory cortex.PLoS computational biology · 2020Article
- Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents.Frontiers in neural circuits · 2020Review
- The implicit learning of metrical and non-metrical rhythms in blind and sighted adults.Psychological research · 2019Article
- Top-down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons.The Journal of physiology · 2019Article
- Increased cortical reactivity to repeated tones at 8 months in infants with later ASD.Translational psychiatry · 2019Article
- GABAergic and cholinergic modulation of repetition suppression in inferior temporal cortex.Scientific reports · 2018Article
- [Effects of auditory response patterns on stimulus-specific adaptation of inferior colliculus neurons in awake mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Modeling Neural Adaptation in Auditory Cortex.Frontiers in neural circuits · 2018Article
- Neurons along the auditory pathway exhibit a hierarchical organization of prediction error.Nature communications · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Stimulus-specific adaptation (SSA), which describes adaptation to repeated sounds concurrent with the maintenance of responsiveness to uncommon ones, may be an important neuronal mechanism for the detection of and attendance to rare stimuli or for the detection of deviance. It is well known that GABAergic neurotransmission regulates several different response properties in central auditory system neurons and that GABA is the major inhibitory neurotransmitter acting in the medial geniculate body (MGB). The mechanisms underlying SSA are still poorly understood; therefore, the primary aim of the present study was to examine what role, if any, MGB GABAergic circuits play in the generation and/or modulation of SSA. Microiontophoretic activation of GABA(A) receptors (GABA(A)Rs) with GABA or with the selective GABA(A)R agonist gaboxadol significantly increased SSA (computed with the common SSA index, CSI) by decreasing responses to common stimuli while having a lesser effect on responses to novel stimuli. In contrast, GABA(A)R blockade using gabazine resulted in a significant decrease in SSA. In all cases, decreases in the CSI during gabazine application were accompanied by an increase in firing rate to the stimulus paradigm. The present findings, in conjunction with those of previous studies, suggest that GABA(A)-mediated inhibition does not generate the SSA response, but can regulate the level of SSA sensitivity in a gain control manner. The existence of successive hierarchical levels of processing through the auditory system suggests that the GABAergic circuits act to enhance mechanisms to reduce redundant information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.