Evidence map›Paper›PMID 24099754›Full record

ReviewRegulatory toxicology and pharmacology : RTP2014

Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review.

Elaine A Cohen Hubal, Thea de Wet, Lilo Du Toit, Michael P Firestone, Mathuros Ruchirawat, Jacqueline van Engelen, Carolyn Vickers

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regulatory toxicology and pharmacology : RTP, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The Research Domain Criteria (RDoC) and Youth Depression - In Context.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2026
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  11. Age-stratified neurosurgical outcomes for traumatic brain injury in a pediatric neurosurgical cohort in La Paz, Bolivia.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elaine A Cohen HubalNational Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: Hubal.Elaine@epamail.epa.gov.
Thea de WetCentre for Anthropological Research and Department of Anthropology and Development Studies, The University of Johannesburg, Auckland Park, South Africa. Electronic address: tdewet@uj.ac.za.
Lilo Du ToitCentre for Rural Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: Lilo.Dutoit@wits.ac.za.
Michael P FirestoneRegulatory Support & Science Policy Division, Office of Children's Health Protection (MC 1107T), Office of the Administrator, U.S. Environmental Protection Agency, Room 1130 EPA West Building, 1200 Pennsylvania Avenue, N.W., Washington, DC 20460, USA. Electronic address: Firestone.michael@epa.gov.
Mathuros RuchirawatOffice of Research, Chulabhorn Research Institute, 54 Kamphaeng-phet 6 Road, Laksi, Bangkok 10210, Thailand. Electronic address: mathuros@cri.or.th.
Jacqueline van EngelenCenter for Sustainability, Environment and Health, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: jacqueline.van.engelen@rivm.nl.
Carolyn VickersInternational Programme on Chemical Safety, World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland. Electronic address: vickersc@who.int.

Funding

World Health Organization 001
6 · The paper itself

Abstract

In this paper, we summarize exposure-related issues to consider in determining the most appropriate age ranges and life stages for risk assessment. We then propose a harmonized set of age bins for monitoring and assessing risks from exposures to chemicals for global use. The focus is on preconception through adolescence, though the approach should be applicable to additional life stages. A two-tiered set of early life age groups is recommended. The first tier involves the adoption of guidance similar to the childhood age groups recommended by the U.S. Environmental Protection Agency, whereas the second tier consolidates some of those age groups to reduce the burden of developing age-specific exposure factors for different regions. While there is no single "correct" means of choosing a common set of age groups to use internationally in assessing early life exposure and risk, use of a set of defined age groups is recommended to facilitate comparisons of potential exposures and risks around the globe, the collection of data and analyses of aggregate exposure and cumulative risk. Application of these age groups for robust assessment of exposure and risk for specific populations will require region-specific exposure factors as well as local environmental monitoring data.

Indexed as

AnimalsEnvironmental ExposureEnvironmental MonitoringEnvironmental PollutantsEnvironmental PollutionHumansRisk AssessmentUnited StatesUnited States Environmental Protection AgencyWorld Health OrganizationEnvironmental PollutantsChildhood life stagesCultural and geographic modifying factorsDevelopmental changes in childrenExposure assessmentExposure factorsExposure to environmental contaminantsHarmonized early life age groupsRisk assessmentWindows of exposureWindows of susceptibility

Identifiers

PMID24099754
PMCPMC5355211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.