ArticleVeterinary research2013
Evaluation of age-dependent susceptibility in calves infected with two doses of Mycobacterium avium subspecies paratuberculosis using pathology and tissue culture.
Article in Veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- Evaluation of the Johne's disease surveillance program in dairy herds in Hokkaido, Japan, using a stochastic individual-based simulation model.The Journal of veterinary medical science · 2026Article
- Risk factors associated with Johne's disease in a captive wood bison herd.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Integrating transcriptomic and genomic studies for the identification of expression quantitative trait loci associated with bovine paratuberculosis.Frontiers in veterinary science · 2025Review
- Lining the small intestine with mycobacteriophages protects fromProceedings of the National Academy of Sciences of the United States of America · 2024Article
- No Evidence of Neutrophil Response Modulation in Goats after Immunization against Paratuberculosis with a Heat-Inactivated Vaccine.Animals : an open access journal from MDPI · 2024Article
- Evaluation ofFrontiers in cellular and infection microbiology · 2023Article
- Immunogenicity and efficacy of an oral live-attenuated vaccine for bovine Johne's disease.Frontiers in immunology · 2023Article
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Identification of Mycobacterium avium subspecies paratuberculosis in sheep farms in Bayannaoer, Inner Mongolia, China (short communication).BMC veterinary research · 2022Article
- Identification of essential genes inFrontiers in microbiology · 2022Article
- Attempted Control of Paratuberculosis in Dairy Calves by Only Changing the Quality of Milk Fed to Calves.Animals : an open access journal from MDPI · 2021Article
- What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?Journal of translational autoimmunity · 2021Review
- Regional Dichotomy in Enteric Mucosal Immune Responses to a PersistentFrontiers in immunology · 2020Article
- Johne's disease in Irish dairy herds: considerations for an effective national control programme.Irish veterinary journal · 2020Review
- Quantifying transmission of Mycobacterium avium subsp. paratuberculosis among group-housed dairy calves.Veterinary research · 2019Article
- Genetic diversity of bovineJournal of veterinary science · 2018Article
- Effects of freezing on ability to detect Mycobacterium avium subsp. paratuberculosis from bovine tissues following culture.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018Article
- Control measures to prevent the increase of paratuberculosis prevalence in dairy cattle herds: an individual-based modelling approach.Veterinary research · 2018Article
- Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis.Heliyon · 2018Article
- Fecal shedding and tissue infections demonstrate transmission of Mycobacterium avium subsp. paratuberculosis in group-housed dairy calves.Veterinary research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The longstanding assumption that calves of more than 6 months of age are more resistant to Mycobacterium avium subspecies paratuberculosis (MAP) infection has recently been challenged. In order to elucidate this, a challenge experiment was performed to evaluate age- and dose-dependent susceptibility to MAP infection in dairy calves. Fifty-six calves from MAP-negative dams were randomly allocated to 10 MAP challenge groups (5 animals per group) and a negative control group (6 calves). Calves were inoculated orally on 2 consecutive days at 5 ages: 2 weeks and 3, 6, 9 or 12 months. Within each age group 5 calves received either a high - or low - dose of 5 × 10⁹ CFU or 5 × 10⁷ CFU, respectively. All calves were euthanized at 17 months of age. Macroscopic and histological lesions were assessed and bacterial culture was done on numerous tissue samples. Within all 5 age groups, calves were successfully infected with either dose of MAP. Calves inoculated at < 6 months usually had more culture-positive tissue locations and higher histological lesion scores. Furthermore, those infected with a high dose had more severe scores for histologic and macroscopic lesions as well as more culture-positive tissue locations compared to calves infected with a low dose. In conclusion, calves to 1 year of age were susceptible to MAP infection and a high infection dose produced more severe lesions than a low dose.
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