ArticleThe Kaohsiung journal of medical sciences2013
Regulatory expression of MMP-8/MMP-9 and inhibition of proliferation, migration and invasion in human lung cancer A549 cells in the presence of HGF variants.
Article in The Kaohsiung journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The Role of MMP8 in Cancer: A Systematic Review.International journal of molecular sciences · 2019Pooled it
- Article
- Lipofection of Single Guide RNA TargetingMedicina (Kaunas, Lithuania) · 2021Article
- Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling.Journal of translational medicine · 2018Article
- Antiproliferation activities of NK4 on multiple myeloma.Experimental and therapeutic medicine · 2018Article
- Murine neutrophils treated with alphaB-crystallin reduce IL-12p40 production by dendritic cells.Immunology · 2018Article
- Efficacy of radiotherapy on intermediate and advanced lung cancer and its effect on dynamic changes of serum vascular endothelial growth factor and matrix metalloproteinase-9.Oncology letters · 2018Article
- Potential role of HGF-PARP-1 signaling in invasion of ovarian cancer cells.International journal of clinical and experimental pathology · 2018Article
- Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9.Molecules (Basel, Switzerland) · 2017Article
- Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing.Stem cells international · 2016Article
- Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) prognostic value in lung adenocarcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells.Journal of Cancer · 2015Article
- Hepatocyte Growth Factor Isoforms in Tissue Repair, Cancer, and Fibrotic Remodeling.Biomedicines · 2014Review
- Telmisartan exerts anti-tumor effects by activating peroxisome proliferator-activated receptor-γ in human lung adenocarcinoma A549 cells.Molecules (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocyte growth factor (HGF), a potent cytokine of mesenchymal origin, exhibits polytrophic physiological responses, including proliferation, migration, and invasion, in a wide variety of cells. Although it is known that inhibition of the responses by HGF variants was via signal transducers and activators of the transcription pathway, the mechanisms of action of the variants involved in the production of matrix metalloproteinases (MMPs) were not clearly understood. Thus, recombinant HGF variants, NK1, NK2, NK3, and NK4 were topically applied to assays for proliferation, migration, invasion, and expression of MMPs in the human lung cancer cell line A549 and compared to that of control medium and a glutathione-s-transferase control. Results showed that these recombinant HGF variants significantly inhibited proliferation, migration, and invasion of A549 at >4 nM, downregulated expression of MMP-9, and upregulated expression of MMP-8. The study clearly suggests that binding of the HGF variants to the cell surface c-Met resulted in the downregulation of MMP-9, and upregulation of MMP-8 protein expressions might be key molecular signals against proliferation, migration, and invasion of A549 cells.
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Registered trials
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