ArticleTissue engineering. Part A2014
New bio-ceramization processes applied to vegetable hierarchical structures for bone regeneration: an experimental model in sheep.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Bioactive glass for periodontal regeneration: a systematic review.BMC oral health · 2023Pooled it
- Platelet-rich plasma for the treatment of bone defects: from pre-clinical rational to evidence in the clinical practice. A systematic review.International orthopaedics · 2017Pooled it
- The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature-A Systematic Review.BioMed research international · 2017Pooled it
- "Anti-Bios": Can Local Antibiotics Affect Bone Union in Infected Bone Defects Treated with Degradable Bone Substitutes.Biomedicines · 2025Article
- Conventional Manufacturing by Pouring Versus Additive Manufacturing Technology of β-Tricalcium Phosphate Bone Substitute Implants.Biomedicines · 2024Article
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
- Preliminary osteogenic and antibacterial investigations of wood derived antibiotic-loaded bone substitute for the treatment of infected bone defects.Frontiers in bioengineering and biotechnology · 2024Article
- External fixator-assisted plating osteosynthesis in a rabbit model of femoral bone defects appears to be a feasible and reproducible surgical technique: preliminary insights from a bone substitute study.Journal of experimental orthopaedics · 2023Article
- Wood as Possible Renewable Material for Bone Implants-Literature Review.Journal of functional biomaterials · 2023Review
- Evaluation of Human Bone Marrow Mesenchymal Stromal Cell (MSC) Functions on a Biomorphic Rattan-Wood-Derived Scaffold: A Comparison between Cultured and Uncultured MSCs.Bioengineering (Basel, Switzerland) · 2021Article
- In Vitro Corrosion of SiC-Coated Anodized Ti Nano-Tubular Surfaces.Journal of functional biomaterials · 2021Article
- Biomorphic Transformations: A Leap Forward in Getting Nanostructured 3-D Bioceramics.Frontiers in chemistry · 2021Review
- Biomaterials for bone regeneration: an orthopedic and dentistry overview.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Review
- Demonstration of a SiC Protective Coating for Titanium Implants.Materials (Basel, Switzerland) · 2020Article
- Annealing and NMaterials (Basel, Switzerland) · 2020Article
- Novel Coating to Minimize Corrosion of Glass-Ceramics for Dental Applications.Materials (Basel, Switzerland) · 2020Article
- The Few Who Made It: Commercially and Clinically Successful Innovative Bone Grafts.Frontiers in bioengineering and biotechnology · 2020Review
- Nanostructured Biomaterials for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- Electrospun Icariin-Loaded Core-Shell Collagen, Polycaprolactone, Hydroxyapatite Composite Scaffolds for the Repair of Rabbit Tibia Bone Defects.International journal of nanomedicine · 2020Article
- Drug-Loaded Biomimetic Ceramics for Tissue Engineering.Pharmaceutics · 2018Review
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone loss is still a major problem in orthopedics. The purpose of this experimental study is to evaluate the safety and regenerative potential of a new scaffold based on a bio-ceramization process for bone regeneration in long diaphyseal defects in a sheep model. The scaffold was obtained by transformation of wood pieces into porous biomorphic silicon carbide (BioSiC®). The process enabled the maintenance of the original wood microstructure, thus exhibiting hierarchically organized porosity and high mechanical strength. To improve cell adhesion and osseointegration, the external surface of the hollow cylinder was made more bioactive by electrodeposition of a uniform layer of collagen fibers that were mineralized with biomimetic hydroxyapatite, whereas the internal part was filled with a bio-hybrid HA/collagen composite. The final scaffold was then implanted in the metatarsus of 15 crossbred (Merinos-Sarda) adult sheep, divided into 3 groups: scaffold alone, scaffold with platelet-rich plasma (PRP) augmentation, and scaffold with bone marrow stromal cells (BMSCs) added during implantation. Radiological analysis was performed at 4, 8, 12 weeks, and 4 months, when animals were sacrificed for the final radiological, histological, and histomorphometric evaluation. In all tested treatments, these analyses highlighted the presence of newly formed bone at the bone scaffolds' interface. Although a lack of substantial effect of PRP was demonstrated, the scaffold+BMSC augmentation showed the highest value of bone-to-implant contact and new bone growth inside the scaffold. The findings of this study suggest the potential of bio-ceramization processes applied to vegetable hierarchical structures for the production of wood-derived bone scaffolds, and document a suitable augmentation procedure in enhancing bone regeneration, particularly when combined with BMSCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.