ArticlePLoS neglected tropical diseases2013
The incubation period of Buruli ulcer (Mycobacterium ulcerans infection).
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transmission models of Mycobacterium ulcerans: A systematic review.PLoS neglected tropical diseases · 2025Pooled it
- Autodissemination stations suppress Aedes notoscriptus mosquitoes and reduce Buruli ulcer risk in urban Australia: a randomized controlled field trial.Nature microbiology · 2026Trial
- Comparative analysis of Buruli ulcer in Ghana and Côte d'Ivoire: A cross-sectional study.PLoS neglected tropical diseases · 2026Article
- Defining new Buruli ulcer endemic areas in urban southeastern Australia using bacterial genomics-informed possum excreta surveys.Applied and environmental microbiology · 2025Article
- Successful treatment with joint retention of Mycobacterium ulcerans prosthetic joint infection in a patient with rheumatoid arthritis.PLoS neglected tropical diseases · 2025Article
- A refined low-dose murine model ofmBio · 2025Article
- Management of Mycobacterium ulcerans infection (Buruli ulcer) in Australia: consensus statement.The Medical journal of Australia · 2025Article
- Improved protocols for isolation of Mycobacterium ulcerans from clinical samples.BMC microbiology · 2025Article
- Buruli ulcer in Australia: Evidence for a new endemic focus at Batemans Bay, New South Wales.PLoS neglected tropical diseases · 2024Article
- Buruli ulcer surveillance in south-eastern Australian possums: Infection status, lesion mapping and internal distribution of Mycobacterium ulcerans.PLoS neglected tropical diseases · 2024Article
- Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia.Nature microbiology · 2024Article
- Comprehensive Case-Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia.Emerging infectious diseases · 2023Article
- Mycobacterium ulcerans not detected by PCR on human skin in Buruli ulcer endemic areas of south eastern Australia.PLoS neglected tropical diseases · 2023Article
- A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.PLoS neglected tropical diseases · 2023Review
- Statistical modeling based on structured surveys of Australian native possum excreta harboringeLife · 2023Article
- Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer.PLoS neglected tropical diseases · 2021Review
- Vaccine-Specific Immune Responses against Mycobacterium ulcerans Infection in a Low-Dose Murine Challenge Model.Infection and immunity · 2020Article
- Providing insight into the incubation period of Mycobacterium ulcerans disease: two case reports.Journal of medical case reports · 2019Article
- The gendered impact of Buruli ulcer on the household production of health and social support networks: Why decentralization favors women.PLoS neglected tropical diseases · 2019Article
- Confirmed Case of Buruli Ulcer, Senegal, 2018.Emerging infectious diseases · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBuruli Ulcer (BU) is caused by the environmental microbe Mycobacterium ulcerans. Despite unclear transmission, contact with a BU endemic region is the key known risk factor. In Victoria, Australia, where endemic areas have been carefully mapped, we aimed to estimate the Incubation Period (IP) of BU by interviewing patients who reported defined periods of contact with an endemic area prior to BU diagnosis.
methodA retrospective review was undertaken of 408 notifications of BU in Victoria from 2002 to 2012. Telephone interviews using a structured questionnaire and review of notification records were performed. Patients with a single visit exposure to a defined endemic area were included and the period from exposure to disease onset determined (IP).
resultsWe identified 111 of 408 notified patients (27%) who had a residential address outside a known endemic area, of whom 23 (6%) reported a single visit exposure within the previous 24 months. The median age of included patients was 30 years (range: 6 to 73) and 65% were male. 61% had visited the Bellarine Peninsula, currently the most active endemic area. The median time from symptom onset to diagnosis was 71 days (range: 34-204 days). The midpoint of the reported IP range was utilized to calculate a point estimate of the IP for each case. Subsequently, the mean IP for the cohort was calculated at 135 days (IQR: 109-160; CI 95%: 113.9-156), corresponding to 4.5 months or 19.2 weeks. The shortest IP recorded was 32 days and longest 264 days (Figure 1 & 2). IP did not vary for variables investigated.
conclusionsThe estimated mean IP of BU in Victoria is 135 days (IQR: 109-160 days), 4.5 months. The shortest recorded was IP 34 days and longest 264 days. A greater understanding of BU IP will aid clinical risk assessment and future research.
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