ArticlePloS one2013
Reproducibility of post-amphetamine [11C]FLB 457 binding to cortical D2/3 receptors.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis.Schizophrenia (Heidelberg, Germany) · 2025Review
- All-Atom Molecular Dynamics Investigations on the Interactions between D2 Subunit Dopamine Receptors and ThreeInternational journal of molecular sciences · 2022Article
- Imaging Cortical Dopamine Transmission in Cocaine Dependence: A [Biological psychiatry · 2020Article
- Stability of acute responses to drugs in humans across repeated testing: Findings with alcohol and amphetamine.Drug and alcohol dependence · 2020Article
- Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Preliminary data indicating a connection between stress-induced prefrontal dopamine release and hippocampal TSPO expression in the psychosis spectrum.Schizophrenia research · 2019Article
- Impaired Prefrontal Cortical Dopamine Release in Schizophrenia During a Cognitive Task: A [11C]FLB 457 Positron Emission Tomography Study.Schizophrenia bulletin · 2019Article
- Failure to detect amphetamine-induced dopamine release in the cortex with [Synapse (New York, N.Y.) · 2018Article
- The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients.NeuroImage. Clinical · 2016Article
- Application of cross-species PET imaging to assess neurotransmitter release in brain.Psychopharmacology · 2015Review
- Measuring cigarette smoking-induced cortical dopamine release: A [¹¹C]FLB-457 PET study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Decreased prefrontal cortical dopamine transmission in alcoholism.The American journal of psychiatry · 2014Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
In a recent positron emission tomography (PET) study, we demonstrated the ability to measure amphetamine-induced dopamine (DA) release in the human cortex with the relatively high affinity dopamine D2/3 radioligand [(11)C]FLB 457. Herein we report on reproducibility and reliability of [(11)C]FLB 457 binding potential relative to non-displaceable uptake (BP(ND)) following an acute amphetamine challenge. Ten healthy human subjects were studied twice with [(11)C]FLB 457 following an acute amphetamine (oral, 0.5 mg kg(-1) dose) challenge on two-separate days approximately one week apart. D2/3 receptor binding parameters were estimated using a two-tissue compartment kinetic analysis in the cortical regions of interest and cerebellum (reference region). The test-retest variability and intraclass correlation coefficient were assessed for distribution volume (V(T)), binding potential relative to plasma concentration (BP(P)), and BP(ND) of [(11)C]FLB 457. The test-retest variability of [(11)C]FLB 457 V(T), BP(P) and BP(ND) were ≤ 17%, 22% and 11% respectively. These results, which are consistent with the published test-retest variability for this ligand measured under baseline conditions demonstrate that the post-amphetamine [(11)C]FLB 457 BP(ND) is reproducible. These data further support the use [(11)C]FLB 457 and amphetamine to characterize cortical dopamine transmission in neuropsychiatric disorders.
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