ArticlePloS one2013
The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Assessing Microstructural and Molecular Brain Changes in Early Cognitive Decline Using Multiparametric 3T Magnetic Resonance Imaging.Neurology international · 2026Article
- 3D quantitative synthetic MRI for assessing Alzheimer's clinical syndrome, subjective cognitive impairment, and mild cognitive impairment.Neuroradiology · 2026Article
- Associations Between Hippocampal Transverse Relaxation Time and Amyloid PET in Cognitively Normal Aging Adults.Journal of magnetic resonance imaging : JMRI · 2026Article
- Quantitative magnetic resonance imaging in Alzheimer's disease: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Plasma Hepcidin as a potential informative biomarker of Alzheimer disease and vascular dementia.Alzheimer's research & therapy · 2025Article
- T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.Human brain mapping · 2023Observational
- Constructing a prognostic risk model for Alzheimer's disease based on ferroptosis.Frontiers in aging neuroscience · 2023Article
- Phase-based fast 3D high-resolution quantitative TScientific reports · 2022Article
- Effects of lipoic acid supplementation on age- and iron-induced memory impairment, mitochondrial DNA damage and antioxidant responses.European journal of nutrition · 2021Article
- The cognitive dysfunction related to Alzheimer disease or cerebral small vessel disease: What's the differences.Medicine · 2021Article
- Three-dimensional whole-brain simultaneous T1, T2, and T1ρ quantification using MR Multitasking: Method and initial clinical experience in tissue characterization of multiple sclerosis.Magnetic resonance in medicine · 2021Article
- Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives.Brain sciences · 2021Review
- Quantitative Analysis of Synthetic Magnetic Resonance Imaging in Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Iron and Ferroptosis as Therapeutic Targets in Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment.Alzheimer's research & therapy · 2020Article
- Plasma transferrin and hemopexin are associated with altered Aβ uptake and cognitive decline in Alzheimer's disease pathology.Alzheimer's research & therapy · 2020Article
- Iron Overload Impairs Autophagy: Effects of Rapamycin in Ameliorating Iron-Related Memory Deficits.Molecular neurobiology · 2020Article
- Potential clinical impact of multiparametric quantitative MR spectroscopy in neurological disorders: A review and analysis.Magnetic resonance in medicine · 2020Review
- Treating Alzheimer's disease by targeting iron.British journal of pharmacology · 2019Review
- Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2019Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectives1) To deduce T2, the inverse of the transverse relaxation rate (R2), in the hippocampus of healthy adults; 2) to investigate the brain iron deposition in Alzheimer's disease (AD) patients and age-matched healthy controls using T2-values.
methodsT2-weighted data from the bilateral-hippocampi of ten AD patients and sixty healthy controls were collected at six echo time points using multi-slice multi-echo turbo spin echo (MSME-TSE) imaging on a 3.0 T MR-scanner, followed by the neuropsychological testing. The correlations between T2-values and Mini-Mental State Examination (MMSE) scores were investigated on group-wise basis (covariates in the group-wise analyses: gender, age, side and healthy/AD).
resultsThere were no significant differences in hippocampal T2-values on intra-gender and inter-gender basis (P > 0.05). Hippocampal T2-values of both sides were similar (right: 85.2±2.4 milliseconds; left: 85.3±2.5 milliseconds). The bilateral hippocampal T2 values correlated moderately with age (right: r = -0.59; left: -0.58; P < 0.001). The AD-group had significantly lower T2-values in the hippocampus when compared to normal controls (P < 0.001) and such low T2-values had a strong positive correlation with the MMSE score (R (2) = 0.97; P < 0.05).
conclusionPatients with AD showed significantly lower T2 values, which can be attributed to the increased iron depositions in the hippocampus. A positive correlation between T2-values and cognition scores suggests that quantitative T2 can be used in the early diagnosis of AD and in the monitoring of the treatment response.
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