ArticlePloS one2013
Small nerve fiber pathology in critical illness.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03893058 (Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.), which is not on this map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the NeuroMuscular Junction Using the Single Fiber Electromyography and Reliability of Train-Of-Four in Critically Ill Patients.
Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.Critical care (London, England) · 2023Review
- Characteristics and influence on quality of life of new-onset pain in critical COVID-19 survivors.European journal of pain (London, England) · 2022Article
- Muscular weakness and muscle wasting in the critically ill.Journal of cachexia, sarcopenia and muscle · 2020Review
- Chronic pain in critical care survivors: a narrative review.British journal of anaesthesia · 2019Review
- Electrophysiologic alterations in the excitability of the sciatic and vagus nerves during early stages of sepsis.Journal of pain research · 2018Article
- [Critical illness myopathy and polyneuropathy].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- The ICM research agenda on intensive care unit-acquired weakness.Intensive care medicine · 2017Review
- Neurogenic orthostatic hypotension with critical illness neuropathy treated with droxidopa.Autonomic neuroscience : basic & clinical · 2016Article
- The impairment of small nerve fibers in severe sepsis and septic shock.Critical care (London, England) · 2016Article
- [Critical illness polyneuropathy and myopathy as neurological complications of sepsis].Der Nervenarzt · 2016Review
- Clinical review: intensive care unit acquired weakness.Critical care (London, England) · 2015Review
- Neuromuscular issues in systemic disease.Current neurology and neuroscience reports · 2015Review
- Insights and limits of translational research in critical care medicine.Annals of intensive care · 2015Article
- Association of Statins with Sensory and Autonomic Ganglionopathy.Frontiers in aging neuroscience · 2015Article
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Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDegeneration of intraepidermal nerve fibers (IENF) is a hallmark of small fiber neuropathy of different etiology, whose clinical picture is dominated by neuropathic pain. It is unknown if critical illness can affect IENF.
methodsWe enrolled 14 adult neurocritical care patients with prolonged intensive care unit (ICU) stay and artificial ventilation (≥ 3 days), and no previous history or risk factors for neuromuscular disease. All patients underwent neurological examination including evaluation of consciousness, sensory functions, muscle strength, nerve conduction study and needle electromyography, autonomic dysfunction using the finger wrinkling test, and skin biopsy for quantification of IENF and sweat gland innervation density during ICU stay and at follow-up visit. Development of infection, sepsis and multiple organ failure was recorded throughout the ICU stay.
resultsOf the 14 patients recruited, 13 (93%) had infections, sepsis or multiple organ failure. All had severe and non-length dependent loss of IENF. Sweat gland innervation was reduced in all except one patient. Of the 7 patients available for follow-up visit, three complained of diffuse sensory loss and burning pain, and another three showed clinical dysautonomia.
conclusionsSmall fiber pathology can develop in the acute phase of critical illness and may explain chronic sensory impairment and pain in neurocritical care survivors. Its impact on long term disability warrants further studies involving also non-neurologic critical care patients.
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