ArticlePloS one2013
Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 75 citations in OpenAlex.
- Preliminary Transcriptomic Insights into the Combined Pathogenesis of Avian Leukosis Virus andVeterinary sciences · 2026Article
- Short-Term Dietary Exposure to Ochratoxin A, Zearalenone or Fumonisins in Broiler Chickens: Effects on Cytochrome P450 Enzymes, Drug Transporters and Antioxidant Defence Systems.Foods (Basel, Switzerland) · 2025Article
- Biochemical and Genomic Underpinnings of Carotenoid Colour Variation Across a Hybrid Zone Between South Asian Flameback Woodpeckers.Molecular ecology · 2025Article
- Alterations in gut microbiota and insights into the colonic function by clodronate: a study using short bowel syndrome rat model.Pediatric surgery international · 2025Article
- Hepatic Transcriptomics of Broilers with Low and High Feed Conversion in Response to Caloric Restriction.Metabolites · 2024Article
- Characterization of Neonicotinoid Metabolites by Cytochrome P450-Mediated Metabolism in Poultry.Toxics · 2024Article
- Physiological changes in the regulation of calcium and phosphorus utilization that occur after the onset of egg production in commercial laying hens.Frontiers in physiology · 2024Article
- A Comparative Genomic and Phylogenetic Investigation of the Xenobiotic Metabolism Enzymes of Cytochrome P450 in Elephants Shows Loss in CYP2E and CYP4A.Animals : an open access journal from MDPI · 2023Article
- The Energy and Nutritional Value of Meat of Broiler Chickens Fed with Various Addition of Wheat Germ Expeller.Animals : an open access journal from MDPI · 2023Article
- Physiological regulation of calcium and phosphorus utilization in laying hens.Frontiers in physiology · 2023Review
- Possible Mechanisms of the Interplay between Drugs and Mycotoxins-Is There a Possible Impact?Toxins · 2022Review
- Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria).Animals : an open access journal from MDPI · 2022Article
- Hepatic Gene Expression Profiling of American Kestrels (Biology · 2022Article
- Tolerability of Atovaquone-Proguanil Application in Common Buzzard Nestlings.Veterinary sciences · 2022Article
- Effect of cytochrome P450 inhibition on toxicity of diclofenac in chickens: Unravelling toxicity in Gyps vultures.The Onderstepoort journal of veterinary research · 2022Article
- Effects of berberine on the pharmacokinetics of florfenicol and levels of cytochrome P450 3A37, multidrug resistance 1, and chicken xenobiotic-sensing orphan nuclear receptor mRNA expression in broilers.Veterinary medicine and science · 2022Article
- Acute toxicity and metabolism of pesticides in birds.Journal of pesticide science · 2021Article
- Identification of Erythromycin and Clarithromycin Metabolites Formed in Chicken Liver Microsomes Using Liquid Chromatography-High-Resolution Mass Spectrometry.Foods (Basel, Switzerland) · 2021Article
- Dimethyl Sulfoxide: Morphological, Histological, and Molecular View on Developing Chicken Liver.Toxics · 2021Article
- Impacts of Dietary Protein and Prebiotic Inclusion on Liver and Spleen Gene Expression in Hy-Line Brown Caged Layers.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytochrome P450 (CYP) of chicken and other avian species have been studied primarily with microsomes or characterized by cloning and protein expression. However, the overall existing isoforms in avian CYP1-3 families or dominant isoforms in avian xenobiotic metabolism have not yet been elucidated. In this study, we aimed to clarify and classify all of the existing isoforms of CYP1-3 in avian species using available genome assemblies for chicken, zebra finch, and turkey. Furthermore, we performed qRT-PCR assay to identify dominant CYP genes in chicken liver. Our results suggested that avian xenobiotic-metabolizing CYP genes have undergone unique evolution such as CYP2C and CYP3A genes, which have undergone avian-specific gene duplications. qRT-PCR experiments showed that CYP2C45 was the most highly expressed isoform in chicken liver, while CYP2C23b was the most highly induced gene by phenobarbital. Considering together with the result of further enzymatic characterization, CYP2C45 may have a dominant role in chicken xenobiotic metabolism due to the constitutive high expression levels, while CYP2C23a and CYP2C23b can be greatly induced by chicken xenobiotic receptor (CXR) activators. These findings will provide not only novel insights into avian xenobiotic metabolism, but also a basis for the further characterization of each CYP gene.
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