ArticlePloS one2013
Haplotype variation of Glu-D1 locus and the origin of Glu-D1d allele conferring superior end-use qualities in common wheat.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 25 citations in OpenAlex.
- Development of PCR-based markers for the identification of wheat HMW glutenin subunit alleles at the GLU-A1 and GLU-D1 loci.Scientific reports · 2025Article
- Molecular characterization of novel high-molecular-weight glutenin subunit genes fromFrontiers in plant science · 2025Article
- High molecular weight glutenin gene diversity in Aegilops tauschii demonstrates unique origin of superior wheat quality.Communications biology · 2021Article
- Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Low molecular weight glutenin subunit gene composition at Glu-D3 loci of Aegilops tauschii and common wheat and a further view of wheat evolution.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Allelic variation of high molecular weight glutenin subunits of bread wheat in Hebei province of China.Journal of genetics · 2018Article
- New insight into the function of wheat glutenin proteins as investigated with two series of genetic mutants.Scientific reports · 2017Article
- Development of a new set of molecular markers for examining Glu-A1 variants in common wheat and ancestral species.PloS one · 2017Article
- A Catalog of Regulatory Sequences for Trait Gene for the Genome Editing of Wheat.Frontiers in plant science · 2016Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In higher plants, seed storage proteins (SSPs) are frequently expressed from complex gene families, and allelic variation of SSP genes often affects the quality traits of crops. In common wheat, the Glu-D1 locus, encoding 1Dx and 1Dy SSPs, has multiple alleles. The Glu-D1d allele frequently confers superior end-use qualities to commercial wheat varieties. Here, we studied the haplotype structure of Glu-D1 genomic region and the origin of Glu-D1d. Using seven diagnostic DNA markers, 12 Glu-D1 haplotypes were detected among common wheat, European spelt wheat (T. spelta, a primitive hexaploid relative of common wheat), and Aegilops tauschii (the D genome donor of hexaploid wheat). By comparatively analyzing Glu-D1 haplotypes and their associated 1Dx and 1Dy genes, we deduce that the haplotype carrying Glu-D1d was likely differentiated in the ancestral hexaploid wheat around 10,000 years ago, and was subsequently transmitted to domesticated common wheat and T. spelta. A group of relatively ancient Glu-D1 haplotypes was discovered in Ae. tauschii, which may serve for the evolution of other haplotypes. Moreover, a number of new Glu-D1d variants were found in T. spelta. The main steps in Glu-D1d differentiation are proposed. The implications of our work for enhancing the utility of Glu-D1d in wheat quality improvement and studying the SSP alleles in other crop species are discussed.
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