ArticlePloS one2013
Simulation of platelet, thrombus and erythrocyte hydrodynamic interactions in a 3D arteriole with in vivo comparison.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Recent Advances in Blood Cell-Inspired and Clot Targeted Thrombolytic Therapies.Journal of tissue engineering and regenerative medicine · 2023Review
- Angiographic Baseline Proximal Thrombus Appearance of M1/M2 Occlusions in Mechanical Thrombectomy.Clinical neuroradiology · 2021Article
- A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.PLoS computational biology · 2020Article
- Maternal death and postpartum hemorrhage in sub-Saharan Africa - A pilot study in metropolitan Mozambique.Research and practice in thrombosis and haemostasis · 2020Article
- Applications and Challenges of Machine Learning to Enable Realistic Cellular Simulations.Frontiers in physics · 2020Article
- Red blood cells: the forgotten player in hemostasis and thrombosis.Journal of thrombosis and haemostasis : JTH · 2019Review
- Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.Biophysical journal · 2018Article
- Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact.Mathematical biosciences · 2017Article
- Model predictions of deformation, embolization and permeability of partially obstructive blood clots under variable shear flow.Journal of the Royal Society, Interface · 2017Article
- Bio-inspired nanomedicine strategies for artificial blood components.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Red blood cells in thrombosis.Blood · 2017Review
- Article
- Sub-cellular modeling of platelet transport in blood flow through microchannels with constriction.Soft matter · 2016Article
- Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales.Interface focus · 2015Review
- Continuous Modeling of Arterial Platelet Thrombus Formation Using a Spatial Adsorption Equation.PloS one · 2015Article
- Fluid Mechanics of Blood Clot Formation.Annual review of fluid mechanics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cylindrical blood vessels, ellipsoid platelets and biconcave-shaped deformable erythrocytes (RBCs) are important participants in hemostasis and thrombosis. However, due to the challenge of combining these components in simulation tools, few simulation studies have included all of them in realistic three-dimensional models. In the present study, we apply a recently developed simulation model to incorporate these components and analyze the flow in a thrombotic tubular arteriole, particularly the detailed hydrodynamic interactions between the thrombus shape, RBCs and platelets. It was found that at certain azimuth positions, the velocity drops in the proximity of both the upstream and downstream edge of the thrombus, which is accompanied by a rapid velocity increase in the narrowed region. The RBCs alter the flow profiles significantly from the typical low Reynolds (Re) number flow, and also enhance the deposition of free flowing platelets onto the thrombus. By evaluating the platelet-thrombus interaction and platelet-RBC interaction together, several mechanisms of platelet deposition augmentation are identified. With in vivo data comparison, our model illustrates the potential of future thrombosis studies that incorporate detailed receptor-ligand adhesion modules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.