ArticlePloS one2013
The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.Medicine · 2019Pooled it
- The gut microbiome is associated with brain structure and function in schizophrenia.Scientific reports · 2021Trial
- Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illnessJournal of psychiatry & neuroscience : JPN · 2020Article
- Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior.Frontiers in psychiatry · 2020Review
- Neurogranin regulates sensorimotor gating through cortico-striatal circuitry.Neuropharmacology · 2019Article
- Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia.BMC psychiatry · 2019Article
- Non-coding RNA dysregulation in the amygdala region of schizophrenia patients contributes to the pathogenesis of the disease.Translational psychiatry · 2018Article
- Adaptive testing for multiple traits in a proportional odds model with applications to detect SNP-brain network associations.Genetic epidemiology · 2017Article
- Substantial DNA methylation differences between two major neuronal subtypes in human brain.Nucleic acids research · 2016Article
- Brain structure and function correlates of cognitive subtypes in schizophrenia.Psychiatry research · 2015Article
- Imaging genetics and psychiatric disorders.Current molecular medicine · 2015Review
- Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease.Brain research · 2014Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
The neural mechanisms underlying genetic risk for schizophrenia, a highly heritable psychiatric condition, are still under investigation. New schizophrenia risk genes discovered through genome-wide association studies (GWAS), such as neurogranin (NRGN), can be used to identify these mechanisms. In this study we examined the association of two common NRGN risk single nucleotide polymorphisms (SNPs) with functional and structural brain-based intermediate phenotypes for schizophrenia. We obtained structural, functional MRI and genotype data of 92 schizophrenia patients and 114 healthy volunteers from the multisite Mind Clinical Imaging Consortium study. Two schizophrenia-associated NRGN SNPs (rs12807809 and rs12541) were tested for association with working memory-elicited dorsolateral prefrontal cortex (DLPFC) activity and surface-wide cortical thickness. NRGN rs12541 risk allele homozygotes (TT) displayed increased working memory-related activity in several brain regions, including the left DLPFC, left insula, left somatosensory cortex and the cingulate cortex, when compared to non-risk allele carriers. NRGN rs12807809 non-risk allele (C) carriers showed reduced cortical gray matter thickness compared to risk allele homozygotes (TT) in an area comprising the right pericalcarine gyrus, the right cuneus, and the right lingual gyrus. Our study highlights the effects of schizophrenia risk variants in the NRGN gene on functional and structural brain-based intermediate phenotypes for schizophrenia. These results support recent GWAS findings and further implicate NRGN in the pathophysiology of schizophrenia by suggesting that genetic NRGN risk variants contribute to subtle changes in neural functioning and anatomy that can be quantified with neuroimaging methods.
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Registered trials
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