ArticlePloS one2013
Misuse and dependence on non-prescription codeine analgesics or sedative H1 antihistamines by adults: a cross-sectional investigation in France.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- The Benzydamine Experience: A Systematic Review of Benzydamine Abuse.Current neuropharmacology · 2021Pooled it
- Community pharmacists' role towards preventing abuse or misuse and dependence of codeine-containing analgesic medications in Saudi Arabia: a multicenter cross-sectional study.Frontiers in pharmacology · 2024Article
- Pattern and predictors of medication use among adults in southwestern Nigeria: A community-based cross-sectional study.Pharmacology research & perspectives · 2023Article
- The association between the availability of over the counter codeine and the prevalence of non-medical use.European journal of clinical pharmacology · 2022Article
- Community pharmacists' views and experiences toward over-the-counter medicines misuse and abuse in Saudi Arabia: A qualitative study.Frontiers in pharmacology · 2022Article
- Abuse of Non-opioid Analgesics in Germany: Prevalence and Associations Among Self-Medicated Users.Frontiers in psychiatry · 2022Article
- Cross-sectional study of the prevalence of prescription opioids misuse in French patients with chronic non-cancer pain: An update with the French version of the POMI scale.Frontiers in pharmacology · 2022Article
- A mixed-methods systematic review of the prevalence, reasons, associated harms and risk-reduction interventions of over-the-counter (OTC) medicines misuse, abuse and dependence in adults.Journal of pharmaceutical policy and practice · 2021Review
- Self-Reported Sedative Drug Use Among Students Attending at University of Gondar, Gondar, Northwest, Ethiopia: A Cross-Sectional Study.Substance abuse and rehabilitation · 2021Article
- Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse.Molecules (Basel, Switzerland) · 2020Review
- Impact of Removing Nonprescription Codeine in Australia: Protocol for a Prospective Cohort Study.JMIR research protocols · 2020Article
- Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep.International journal of clinical pharmacy · 2017Article
- Association Between Parenting Stress and Functional Impairment Among Children Diagnosed with Neurodevelopmental Disorders.Community mental health journal · 2017Article
- Abuse of over-the-counter medicines: a pharmacist's perspective.Integrated pharmacy research & practice · 2017Review
- How Resistant to Tampering are Codeine Containing Analgesics on the Market? Assessing the Potential for Opioid Extraction.Pain and therapy · 2016Article
- Pain management in trauma: A review study.Journal of injury & violence research · 2016Review
- [Misuse of opioid analgesics. An internet analysis].Schmerz (Berlin, Germany) · 2014Review
- Widening consumer access to medicines through switching medicines to non-prescription: a six country comparison.PloS one · 2014Article
- Article
- Self-medication consultations in community pharmacy: an exploratory study on teams' performance, client-reported outcomes and satisfaction.Pharmacy practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiven the growing worldwide market of non-prescription drugs, monitoring their misuse in the context of self-medication represents a particular challenge in Public Health. The aim of this study was to investigate the prevalence of misuse, abuse, and dependence on non-prescription psychoactive drugs.
methodDuring one month, in randomly solicited community pharmacies, an anonymous questionnaire was offered to adults requesting paracetamol (control group), codeine combined with paracetamol in analgesics, or sedative H1 antihistamines. Responses about misuse (drug use not in agreement with the Patient Information Leaflet) abuse (excessive drug use having detrimental consequences), and dependence (established according to questions adapted from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria) on psychoactive drugs were compared to those of the paracetamol control group.
results295 patients (mean age 48.5 years, 68.5% of women) having used one of the studied drugs during the previous month were included. Misuse and dependence to codeine analgesics concerned 6.8% and 17.8% of the patients exposed to these drugs, respectively, (n = 118), which was significantly higher than for paracetamol. 19.5% had used codeine analgesics daily for more than six months. Headache was the most frequent reason for persistent daily use. A high prevalence of persistent daily users of sedative H1 antihistamines was also observed. Whereas these drugs are recommended only for short treatment courses of occasional insomnia, 72.2% of the participants having taken doxylamine (n = 36) were daily users, predominantly for more than six months.
conclusionsResults on misuse and dependence on non-prescription codeine analgesics suggest that chronic pain, in particular chronic cephalalgia, requires better medical care. In addition, as for hypnotics on prescription, persistent use of doxylamine for self-medication is not justified until an acceptable benefit-risk ratio for chronic sleep disturbance is shown by clinical data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.