ArticlePloS one2013
Oral community interactions of Filifactor alocis in vitro.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Quorum sensing inFrontiers in oral health · 2025Pooled it
- Arginine metabolism as a mutualistic strategy in the interaction between Porphyromonas gingivalis and Filifactor alocis.Nature communications · 2026Article
- Prevalence ofPathogens (Basel, Switzerland) · 2026Observational
- Functional Characterization of a Putative Sortase FA1364 inInternational journal of molecular sciences · 2026Article
- Article
- Fibrinogen was associated with subgingival microbiome in periodontal diseases: a pilot study.Journal of oral microbiology · 2026Article
- Identification of Bacterial Networks and Relationship to Host Responses in Early Periodontitis Population over 24 Months.International journal of molecular sciences · 2025Article
- Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study.Microbiology spectrum · 2025Article
- Increased bacterial load ofFrontiers in oral health · 2025Article
- A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis.Pathogens (Basel, Switzerland) · 2024Review
- From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024Review
- Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to HMolecular oral microbiology · 2024Article
- Association ofFrontiers in cellular and infection microbiology · 2024Article
- Prevalence of the oral pathogenFrontiers in cellular and infection microbiology · 2024Article
- Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens.Journal of applied oral science : revista FOB · 2023Article
- Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence.NPJ biofilms and microbiomes · 2022Article
- The emerging oral pathogen, Filifactor alocis, extends the functional lifespan of human neutrophils.Molecular microbiology · 2022Article
- Effects ofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Host and bacterial factors linking periodontitis and rheumatoid arthritis.Frontiers in immunology · 2022Review
- Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context.The ISME journal · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Filifactor alocis is a gram positive anaerobe that is emerging as an important periodontal pathogen. In the oral cavity F. alocis colonizes polymicrobial biofilm communities; however, little is known regarding the nature of the interactions between F. alocis and other oral biofilm bacteria. Here we investigate the community interactions of two strains of F. alocis with Streptococcus gordonii, Fusobacterium nucleatum, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, organisms with differing pathogenic potential in the oral cavity. In an in vitro community development model, S. gordonii was antagonistic to the accumulation of F. alocis into a dual species community. In contrast, F. nucleatum and the type strain of F. alocis formed a synergistic partnership. Accumulation of a low passage isolate of F. alocis was also enhanced by F. nucleatum. In three species communities of S. gordonii, F. nucleatum and F. alocis, the antagonistic effects of S. gordonii superseded the synergistic effects of F. nucleatum toward F. alocis. The interaction between A. actinomycetemcomitans and F. alocis was strain specific and A. actinomycetemcomitans could either stimulate F. alocis accumulation or have no effect depending on the strain. P. gingivalis and F. alocis formed heterotypic communities with the amount of P. gingivalis greater than in the absence of F. alocis. However, while P. gingivalis benefited from the relationship, levels of F. alocis in the dual species community were lower compared to F. alocis alone. The inhibitory effect of P. gingivalis toward F. alocis was dependent, at least partially, on the presence of the Mfa1 fimbrial subunit. In addition, AI-2 production by P. gingivalis helped maintain levels of F. alocis. Collectively, these results show that the pattern of F. alocis colonization will be dictated by the spatial composition of microbial microenvironments, and that the organism may preferentially accumulate at sites rich in F. nucleatum.
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Registered trials
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