ArticlePloS one2013
Metagenomic profiling of antibiotic resistance genes and mobile genetic elements in a tannery wastewater treatment plant.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 144 citations in OpenAlex.
- Concordance between environmental resistomes and pathogenic phenotypes: a case study of multidrug-resistantFrontiers in microbiology · 2026Article
- Characterization of enteric pathogens in Harare, Zimbabwe using environmental surveillance and metagenomics.Journal of water and health · 2025Article
- The Impact of Wastewater on Antimicrobial Resistance: A Scoping Review of Transmission Pathways and Contributing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- A Comparative Metagenomic Analysis of Specified Microorganisms in Groundwater for Non-Sterilized Pharmaceutical Products.Current microbiology · 2024Article
- Archaeal and Extremophilic Bacteria from Different Archaeological Excavation Sites.International journal of molecular sciences · 2023Article
- Correlations among Antibiotic Resistance Genes, Mobile Genetic Elements and Microbial Communities in Municipal Sewage Treatment Plants Revealed by High-Throughput Sequencing.International journal of environmental research and public health · 2023Article
- Article
- Demonstrating a Comprehensive Wastewater-Based Surveillance Approach That Differentiates Globally Sourced Resistomes.Environmental science & technology · 2022Article
- Evaluation of the Effects of Library Preparation Procedure and Sample Characteristics on the Accuracy of Metagenomic Profiles.mSystems · 2021Article
- Recovery of gut microbiota in mice exposed to tetracycline hydrochloride and their correlation with host metabolism.Ecotoxicology (London, England) · 2021Article
- Lessons and Considerations for the Creation of Universal Primers Targeting Non-Conserved, Horizontally Mobile Genes.Applied and environmental microbiology · 2021Article
- Investigation of the Prevalence of Antibiotic Resistance Genes According to the Wastewater Treatment Scale Using Metagenomic Analysis.Antibiotics (Basel, Switzerland) · 2021Article
- Climatological and Epidemiological Conditions Are Important Factors Related to the Abundance ofFrontiers in cellular and infection microbiology · 2021Article
- Antimicrobial Drug-Resistant Gram-Negative Saprophytic Bacteria Isolated from Ambient, Near-Shore Sediments of an Urbanized Estuary: Absence of β-Lactamase Drug-Resistance Genes.Antibiotics (Basel, Switzerland) · 2020Article
- The Contribution of Wastewater to the Transmission of Antimicrobial Resistance in the Environment: Implications of Mass Gathering Settings.Tropical medicine and infectious disease · 2020Review
- Exploring the antibiotic resistome in activated sludge and anaerobic digestion sludge in an urban wastewater treatment plant via metagenomic analysis.Journal of microbiology (Seoul, Korea) · 2020Article
- Urbanization and Waterborne Pathogen Emergence in Low-Income Countries: Where and How to Conduct Surveys?International journal of environmental research and public health · 2020Review
- Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge.3 Biotech · 2020Article
- Rhizosphere Metagenomics ofMicroorganisms · 2019Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics are often used to prevent sickness and improve production in animal agriculture, and the residues in animal bodies may enter tannery wastewater during leather production. This study aimed to use Illumina high-throughput sequencing to investigate the occurrence, diversity and abundance of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in aerobic and anaerobic sludge of a full-scale tannery wastewater treatment plant (WWTP). Metagenomic analysis showed that Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria dominated in the WWTP, but the relative abundance of archaea in anaerobic sludge was higher than in aerobic sludge. Sequencing reads from aerobic and anaerobic sludge revealed differences in the abundance of functional genes between both microbial communities. Genes coding for antibiotic resistance were identified in both communities. BLAST analysis against Antibiotic Resistance Genes Database (ARDB) further revealed that aerobic and anaerobic sludge contained various ARGs with high abundance, among which sulfonamide resistance gene sul1 had the highest abundance, occupying over 20% of the total ARGs reads. Tetracycline resistance genes (tet) were highly rich in the anaerobic sludge, among which tet33 had the highest abundance, but was absent in aerobic sludge. Over 70 types of insertion sequences were detected in each sludge sample, and class 1 integrase genes were prevalent in the WWTP. The results highlighted prevalence of ARGs and MGEs in tannery WWTPs, which may deserve more public health concerns.
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