Evidence map›Paper›PMID 24098337›Full record

ArticlePloS one2013

Extrapulmonary tuberculosis: Mycobacterium tuberculosis strains and host risk factors in a large urban setting in Brazil.

Teresa Gomes, Solange Alves Vinhas, Bárbara Reis-Santos, Moisés Palaci, Renata Lyrio Peres, Paola P Aguiar, Fabiola Karla Correa Ribeiro, Hebert Silva Marques, Valdério do Valle Dettoni, John L Johnson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Pooled it
  4. Discrimination betweenOne health (Amsterdam, Netherlands) · 2026
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  13. Difference in Antibody Responses toJournal of immunology research · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Teresa GomesGraduate Program in Infectious Diseases, Federal University of Espírito Santo, Vitória, Brazil.
Solange Alves Vinhas
Bárbara Reis-Santos
Moisés Palaci
Renata Lyrio Peres
Paola P Aguiar
Fabiola Karla Correa Ribeiro
Hebert Silva Marques
Valdério do Valle Dettoni
John L Johnson
Lee W Riley
Ethel Leonor Maciel
Universidade Federal do Espírito Santo · BRCase Western Reserve University · USUniversity of California, Berkeley · US

Funding

Tuberculosis Prevention Research Unit /TBRU/-266095383N01AI095383 · NIAID · CASE WESTERN RESERVE UNIVERSITY · 2000 to 2005
$5.6M
Innovative approaches for tuberculosis control in BrazilU2RTW006883 · FIC · FEDERAL UNIVERSITY OF RIO DE JANEIRO · PI LAPA E SILVA, JOSE ROBERTO · 2005 to 2015
$3.5M
FIC NIH HHS 5 U2R TW006883-02FIC NIH HHS U2R TW006883NIAID NIH HHS HHSN266200700022C/NO1-AI-70022NIAID NIH HHS N01 AI070022NIAID NIH HHS N01 AI095383NIAID NIH HHS N01-AI95383
6 · The paper itself

Abstract

backgroundFactors related to the development of extrapulmonary forms of tuberculosis (EPTB) are still poorly understood, particularly in high-endemic countries like Brazil. The objective of the paper is to determine host and Mycobacterium tuberculosis (MTB) strain-related factors associated with the development of EPTB in Espírito Santo state, Brazil. METHODS AND

findingsWe conducted a retrospective laboratory-based surveillance study of new tuberculosis (TB) cases diagnosed in Espírito Santo state, Brazil between 1998 and 2007. We genotyped 612 isolates of MTB from 606 TB patients using spoligotyping and IS6110-restriction fragment length polymorphism (RFLP) typing and compared sociodemographic and clinical characteristics of patients with pulmonary TB (PTB) and EPTB. Among 606 patients, 464 (77%) had PTB, 79 (13%) had EPTB, 51 (8%) had both, and 12 (2%) had miliary TB. The IS6110 RFLP analysis demonstrated that 250 (41%) isolates belonged to clustered RFLP patterns, 27 (11%) of which were from EPTB. We identified 73 clusters including 35 (48%) composed of 2 isolates each. By spoligotyping, 506 (83%) MTB isolates fell into known patterns and 106 (17%) fell into patterns with no family assignment; 297 (48%) isolates belonged to the Latin-American Mediterranean family. Higher school level (4-7 years OR: 0.16 95% CI 0.34-0.73 and > 8 years of education, OR 0.06 95% CI 0.009-0.50) white ethnicity (OR: 2.54 95% CI 1.03-6.25) and HIV infection (OR: 16.83 95% CI 5.23-54.18) were associated with EPTB. No specific strain lineage or percentage of clustering was associated with EPTB.

conclusionsThese results demonstrate that risk factors for EPTB are related more to host than to MTB strain lineage characteristics.

Indexed as

AdolescentAdultAgedBrazilChildChild, PreschoolCitiesFemaleGenotypeHumansMaleMiddle AgedMycobacterium tuberculosisRetrospective StudiesRisk FactorsSpecies Specificity

Identifiers

PMID24098337
PMCPMC3788772
OpenAlexW2116334455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.