ArticlePloS one2013
Two wheat glutathione peroxidase genes whose products are located in chloroplasts improve salt and H2O2 tolerances in Arabidopsis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- The family of glutathione peroxidase proteins and their role against biotic stress in plants: a systematic review.Frontiers in plant science · 2025Pooled it
- Heterochromatin protein 1 (HP1) dysfunction drives male-biased sex ratio in Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) via paternal genome elimination during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- Harnessing Antioxidants for Abiotic Stress Management: Mechanistic Insights and Prospects for Sustainable Agriculture.Antioxidants (Basel, Switzerland) · 2026Review
- Assessment of key transcription factors and drought-responsive genes in wheat cultivars under drought stress.Journal, genetic engineering & biotechnology · 2026Article
- Comprehensive identification of glutathione peroxidase (GPX) gene family and effect of GhGPX4 on reactive oxygen species metabolism in cotton.Frontiers in plant science · 2026Article
- Development of functional markers and expression analysis for a Peroxidase gene TaPod-A3 on chromosome 7AL in wheat.The plant genome · 2025Article
- The Glutathione Peroxidase Gene Family inAntioxidants (Basel, Switzerland) · 2025Article
- The Manifestation of the Dual ROS-Processing and Redox Signaling Roles of Glutathione Peroxidase-like Enzymes in Development ofAntioxidants (Basel, Switzerland) · 2025Article
- Physiological, biochemical, and transcriptomic alterations in Castor (Ricinus communis L.) under polyethylene glycol-induced oxidative stress.BMC plant biology · 2024Article
- Characterization ofInternational journal of molecular sciences · 2024Article
- Insights into Salinity Tolerance in Wheat.Genes · 2024Review
- Sensitivity and responses of chloroplasts to salt stress in plants.Frontiers in plant science · 2024Review
- Duplicate Genes Contribute to Variability in Abiotic Stress Resistance in Allopolyploid Wheat.Plants (Basel, Switzerland) · 2023Review
- The Glutathione Peroxidase Gene Family inGenes · 2023Article
- Triticum aestivum: antioxidant gene profiling and morpho-physiological studies under salt stress.Molecular biology reports · 2023Article
- Photosynthetic machinery under salinity stress: Trepidations and adaptive mechanisms.Photosynthetica · 2023Review
- Comparative transcriptomic analysis and functional characterization reveals that the class III peroxidase geneFrontiers in plant science · 2023Article
- Plant Glutathione Peroxidases: Non-Heme Peroxidases with Large Functional Flexibility as a Core Component of ROS-Processing Mechanisms and Signalling.Antioxidants (Basel, Switzerland) · 2022Review
- Crosstalk between theInternational journal of molecular sciences · 2022Article
- Deciphering immune responses primed by a bacterial lipopeptide in wheat towardsFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress caused by accumulation of reactive oxygen species (ROS) is capable of damaging effects on numerous cellular components. Glutathione peroxidases (GPXs, EC 1.11.1.9) are key enzymes of the antioxidant network in plants. In this study, W69 and W106, two putative GPX genes, were obtained by de novo transcriptome sequencing of salt-treated wheat (Triticum aestivum) seedlings. The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide. GFP fluorescence assays revealed that W69 and W106 are localized in chloroplasts. Quantitative real-time PCR (Q-RT-PCR) analysis showed that two GPXs were differentially responsive to salt, drought, H2O2, or ABA. Isolation of the W69 and W106 promoters revealed some cis-acting elements responding to abiotic stresses. Overexpression of W69 and W106 conferred strong tolerance to salt, H2O2, and ABA treatment in Arabidopsis. Moreover, the expression levels of key regulator genes (SOS1, RbohD and ABI1/ABI2) involved in salt, H2O2 and ABA signaling were altered in the transgenic plants. These findings suggest that W69 and W106 not only act as scavengers of H2O2 in controlling abiotic stress responses, but also play important roles in salt and ABA signaling.
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