ArticlePLoS pathogens2013
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- The dual roles of uterine monocytes in regulation of tissue homeostasis throughout reproductive cycles in health and disease.Nature immunology · 2026Article
- Selective Packaging of miR-22 and miR-29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis.Journal of extracellular vesicles · 2026Article
- Cytokines from parasites: manipulating host responses by molecular mimicry.The Biochemical journal · 2025Review
- The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.International journal of molecular sciences · 2023Review
- New perspectives on the regulation of germinal center reactionFrontiers in immunology · 2022Review
- Investigation of serum levels of orexin-A, transforming growth factor β, and leptin in patients with multiple sclerosis.Journal of clinical laboratory analysis · 2022Article
- Article
- CD1dFrontiers in immunology · 2021Article
- Article
- Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction.Annual review of neuroscience · 2020Review
- Regulatory T-cells in helminth infection: induction, function and therapeutic potential.Immunology · 2020Review
- Regulation of barrier immunity and homeostasis by integrin-mediated transforming growth factor β activation.Immunology · 2020Review
- Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice.The Journal of clinical investigation · 2019Article
- TGFβ-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice.PLoS pathogens · 2019Article
- Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.The Journal of experimental medicine · 2018Article
- Immunity to gastrointestinal nematode infections.Mucosal immunology · 2018Review
- Immunomodulatory Bonds of the Partnership between Dendritic Cells and T Cells.Critical reviews in immunology · 2018Review
- Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.Mucosal immunology · 2017Article
- Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.Mucosal immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection. We show that, early during development of chronic infection with the murine intestinal parasite Trichuris muris, TGFβ signalling in CD4+ T-cells is induced and that antibody-mediated inhibition of TGFβ function results in protection from infection. Mechanistically, we find that enhanced TGFβ signalling in CD4+ T-cells during infection involves expression of the TGFβ-activating integrin αvβ8 by dendritic cells (DCs), which we have previously shown is highly expressed by a subset of DCs in the intestine. Importantly, mice lacking integrin αvβ8 on DCs were completely resistant to chronic infection with T. muris, indicating an important functional role for integrin αvβ8-mediated TGFβ activation in promoting chronic infection. Protection from infection was dependent on CD4+ T-cells, but appeared independent of Foxp3+ Tregs. Instead, mice lacking integrin αvβ8 expression on DCs displayed an early increase in production of the protective type 2 cytokine IL-13 by CD4+ T-cells, and inhibition of this increase by crossing mice to IL-4 knockout mice restored parasite infection. Our results therefore provide novel insights into how type 2 immunity is controlled in the intestine, and may help contribute to development of new therapies aimed at promoting expulsion of gut helminths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.