ArticleClinical interventions in aging2013
Upregulation of genes related to bone formation by γ-amino butyric acid and γ-oryzanol in germinated brown rice is via the activation of GABAB-receptors and reduction of serum IL-6 in rats.
Article in Clinical interventions in aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Antioxidant, Anti-Inflammatory, and Bone-Remodeling Modulatory Activities of Thai Pigmented and Non-Pigmented Rice Bran Oils Containing Tocols and γ-Oryzanol.Antioxidants (Basel, Switzerland) · 2026Article
- Diet, the Gut Microbiome, and Estrogen Physiology: A Review in Menopausal Health and Interventions.Nutrients · 2026Review
- Baclofen Promotes Osteochondrogenic Commitment of Mesenchymal Stem Cells: Implications for Heterotopic Ossification Risk.International journal of molecular sciences · 2026Article
- Functional benefits of ultra-high hydrostatic pressurized brown rice on cognition, apathy, and bone health in older adults: A 12-month randomized controlled trial.Experimental and therapeutic medicine · 2025Article
- Biochemical, Biological, and Clinical Properties of γ-Oryzanol.Antioxidants (Basel, Switzerland) · 2025Review
- Phyllostachyos Caulis in Taeniam extract stimulates longitudinal bone growth via IGF-1 and JAK2/STAT5 signaling in rats.PloS one · 2025Article
- Shifts in the microbial community and metabolome in rumen ecological niches during antler growth.Computational and structural biotechnology journal · 2024Article
- Clinical efficacy of gamma-oryzanol combined with Femoston for perimenopausal syndrome.World journal of clinical cases · 2024Article
- Integration analysis of pituitary proteome and transcriptome reveals fertility-related biomarkers inFrontiers in endocrinology · 2024Article
- Changes in the composition of gut and vaginal microbiota in patients with postmenopausal osteoporosis.Frontiers in immunology · 2022Article
- Neuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Gut Microbiota and Serum Metabolic Signatures of High-Fat-Induced Bone Loss in Mice.Frontiers in cellular and infection microbiology · 2021Article
- Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats.Nutrition research and practice · 2020Article
- Effect of fermented oyster extract on growth promotion in Sprague-Dawley rats.Integrative medicine research · 2020Article
- Gamma Aminobutyric Acid-Enriched Fermented Oyster (Molecules (Basel, Switzerland) · 2020Article
- Metabolomic profiles associated with bone mineral density in US Caucasian women.Nutrition & metabolism · 2018Article
- Edible Bird's Nest Prevents Menopause-Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin-1 Expression.Oxidative medicine and cellular longevity · 2017Article
- Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts.Molecular medicine reports · 2016Article
- Germinated brown rice ameliorates obesity in high-fat diet induced obese rats.BMC complementary and alternative medicine · 2016Article
- Bone mass density estimation: Archimede's principle versus automatic X-ray histogram and edge detection technique in ovariectomized rats treated with germinated brown rice bioactives.Clinical interventions in aging · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis and other bone degenerative diseases are among the most challenging non-communicable diseases to treat. Previous works relate bone loss due to osteoporosis with oxidative stress generated by free radicals and inflammatory cytokines. Alternative therapy to hormone replacement has been an area of interest to researchers for almost three decades due to hormone therapy-associated side effects.
methodsIn this study, we investigated the effects of gamma-amino butyric acid (GABA), gamma-oryzanol (ORZ), acylated steryl glucosides (ASG), and phenolic extracts from germinated brown rice (GBR) on the expression of genes related to bone metabolism, such as bone morphogenic protein-2 (BMP-2), secreted protein acidic and rich in cysteine (SPARC), runt-related transcription factor 2 (RUNX-2), osteoblast-specific transcription factor osterix (Osx), periostin, osteoblast specific factor (Postn), collagen 1&2 (Col1&2), calcitonin receptor gene (CGRP); body weight measurement and also serum interleukin-6 (IL-6) and osteocalcin, in serum and bone. Rats were treated with GBR, ORZ, GABA, and ASG at (100 and 200 mg/kg); estrogen (0.2 mg/kg), or remifemin (10 and 20 mg/kg), compared to ovariectomized non-treated group as well as non-ovariectomized non-treated (sham) group. Enzyme-linked immunosorbent assay was used to measure the IL-6 and osteocalcin levels at week 2, 4, and 8, while the gene expression in the bone tissue was determined using the Genetic Analysis System (Beckman Coulter Inc., Brea, CA, USA).
resultsThe results indicate that groups treated with GABA (100 and 200 mg/kg) showed significant upregulation of SPARC, calcitonin receptor, and BMP-2 genes (P < 0.05), while the ORZ-treated group (100 and 200 mg/kg) revealed significant (P < 0.05) upregulation of Osx, Postn, RUNX-2, and Col1&2. Similarly, IL-6 concentration decreased, while osteocalcin levels increased significantly (P < 0.05) in the treated groups as compared to ovariectomized non-treated groups.
conclusionGABA and ORZ from GBR stimulates osteoblastogenesis by upregulation of bone formation genes, possibly via the activation of GABAB receptors and by inhibiting the activity of inflammatory cytokines and reactive oxygen species. Therefore, it could be used effectively in the management of osteoporosis.
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