ArticleThe Journal of biological chemistry2013
Search for proteins required for accurate gene expression under oxidative stress: roles of guanylate kinase and RNA polymerase.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
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- Comparative chloroplast genomics reveals the phylogeny and the adaptive evolution of Begonia in China.BMC genomics · 2023Article
- Gene Loss, Pseudogenization in Plastomes of GenusFrontiers in genetics · 2021Article
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- A Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to Antibiotics.PloS one · 2016Article
- Lost in transcription: transient errors in information transfer.Current opinion in microbiology · 2015Review
- Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Nucleic acids research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In aerobically growing cells, in which reactive oxygen species are produced, the guanine base is oxidized to 8-oxo-7,8-dihydroguanine, which can pair with adenine as well as cytosine. This mispairing causes alterations in gene expression, and cells possess mechanisms to prevent such outcomes. In Escherichia coli, 8-oxo-7,8-dihydroguanine-related phenotypic suppression of lacZ amber is enhanced by mutations in genes related to the prevention of abnormal protein synthesis under oxidative stress. A genome-wide search for the genes responsible, followed by DNA sequence determination, revealed that specific amino acid changes in guanylate kinase and in the β and β' subunits of RNA polymerase cause elevated levels of phenotypic suppression, specifically under aerobic conditions. The involvement of the DnaB, DnaN, and MsbA proteins, which are involved in DNA replication and in preserving the membrane structure, was also noted. Interactions of these proteins with each other and also with other molecules may be important for preventing errors in gene expression.
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Registered trials
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