Evidence map›Paper›PMID 24097374›Full record

Trial reportSocial cognitive and affective neuroscience2014

MDMA enhances emotional empathy and prosocial behavior.

Cédric M Hysek, Yasmin Schmid, Linda D Simmler, Gregor Domes, Markus Heinrichs, Christoph Eisenegger, Katrin H Preller, Boris B Quednow, Matthias E Liechti

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03752918 (The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder), which is not on this map. Cited by 166 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 7 pooled it
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03752918 phase1withdrawnnot on this mapstarted 2024, after this paper: background citation

The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder

TypeinterventionalSponsorYale UniversityRan2024 to 2028Enrolled0ConditionsPost Traumatic Stress DisorderArmsMDMA, Niacin
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 7 syntheses or guidelines pooled it, 348 citations in OpenAlex.

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  11. Acute effects of MDMA, MDA, lysine-MDMA, and lysine-MDA in a randomized, double-blind, placebo-controlled, crossover trial in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  15. Acute effects of R-MDMA, S-MDMA, and racemic MDMA in a randomized double-blind cross-over trial in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  17. MDMA enhances positive affective responses to social feedback.Journal of psychopharmacology (Oxford, England) · 2024
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  19. Acute effects of MDMA and LSD co-administration in a double-blind placebo-controlled study in healthy participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Cédric M HysekPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Yasmin SchmidPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Linda D SimmlerPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Gregor DomesPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Markus HeinrichsPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Christoph EiseneggerPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland Psychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Katrin H PrellerPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Boris B QuednowPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland.
Matthias E LiechtiPsychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, 4031 Basel, Switzerland, Laboratory for Biological and Personality Psychology, Department of Psychology, University of Freiburg, 79085 Freiburg, Germany, Department of Psychology, Behavioral and Clinical Neuroscience Institute, University of Cambridge, CB21TN Cambridge, UK, Social, Cognitive and Affective Neuroscience Unit, Faculty of Psychology, University of Vienna, 1010 Vienna, Austria, and Experimental and Clinical Pharmacopsychology, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, 8032 Zurich, Switzerland matthias.liechti@usb.ch.
University of Cambridge · GBUniversity of Basel · CHUniversity of Freiburg · DEUniversity Hospital of Basel · CHUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') releases serotonin and norepinephrine. MDMA is reported to produce empathogenic and prosocial feelings. It is unknown whether MDMA in fact alters empathic concern and prosocial behavior. We investigated the acute effects of MDMA using the Multifaceted Empathy Test (MET), dynamic Face Emotion Recognition Task (FERT) and Social Value Orientation (SVO) test. We also assessed effects of MDMA on plasma levels of hormones involved in social behavior using a placebo-controlled, double-blind, random-order, cross-over design in 32 healthy volunteers (16 women). MDMA enhanced explicit and implicit emotional empathy in the MET and increased prosocial behavior in the SVO test in men. MDMA did not alter cognitive empathy in the MET but impaired the identification of negative emotions, including fearful, angry and sad faces, in the FERT, particularly in women. MDMA increased plasma levels of cortisol and prolactin, which are markers of serotonergic and noradrenergic activity, and of oxytocin, which has been associated with prosocial behavior. In summary, MDMA sex-specifically altered the recognition of emotions, emotional empathy and prosociality. These effects likely enhance sociability when MDMA is used recreationally and may be useful when MDMA is administered in conjunction with psychotherapy in patients with social dysfunction or post-traumatic stress disorder.

Indexed as

Social BehaviorAdultAnalysis of VarianceCross-Over StudiesDouble-Blind MethodEmotionsEmpathyFaceFemaleGlycopeptidesHallucinogensHumansInterpersonal RelationsMaleN-Methyl-3,4-methylenedioxyamphetamineOxytocincopeptinsGlycopeptidesHallucinogensN-Methyl-3,4-methylenedioxyamphetamineOxytocinecstasyemotion recognitionempathyMDMAsocial behaviorsocial cognition

Identifiers

PMID24097374
PMCPMC4221206
OpenAlexW2165032621

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.