Evidence map›Paper›PMID 24097275›Full record

ArticleInternational urology and nephrology2014

Comparison of erythropoietin and sildenafil protective role against ischemia/reperfusion injury of the testis in adult rats.

Nick Zavras, Ioannis D Kostakis, Stratigoula Sakellariou, Christos Damaskos, Evangelos Roupakas, Eleni Tsagkari, Eleftherios Spartalis, Konstantinos Velaoras, Ismene A Dontas, Theodore Karatzas

Abstract readComparative Study
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In one paragraph

Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Nick ZavrasThird Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, 1 Rimini Street, Chaidari, 12462, Athens, Greece.
Ioannis D Kostakis
Stratigoula Sakellariou
Christos Damaskos
Evangelos Roupakas
Eleni Tsagkari
Eleftherios Spartalis
Konstantinos Velaoras
Ismene A Dontas
Theodore Karatzas
National and Kapodistrian University of Athens · GRLaiko General Hospital of Athens · GRAmerican Community Schools · GRPenteli General Children's Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTissue damage in testicular torsion/detorsion is caused not only by the ischemia, but also by the ischemia/reperfusion injury after detorsion. Erythropoietin and sildenafil are considered to protect against ischemia/reperfusion injury. Here, we studied and compared their actions in testicular torsion/detorsion in adult rats.

methodsTwenty-two adult male Wistar Albino rats were divided into four groups. Rats in group A (n = 5) were sham operated. Rats in group B (n = 5), group C (n = 6) and group D (n = 6) underwent torsion of the right testis and detorsion after 90 min. No pharmaceutical intervention was performed in group B. Erythropoietin (1,000 IU/kg) and sildenafil (0.7 mg/kg) were injected intraperitoneally in groups C and D, respectively, after 60 min of torsion. All animals were killed 24 h after detorsion, and their right testis was extracted, placed into 10 % formalin solution and sent for histopathological examination. The histological changes in the testes were scored according to the four-point grading system proposed by Cosentino et al.

resultsAll rats in group A had normal testicular architecture (grade 1). The untreated group B had a mean grade of 3.81 (range 3.65-4). The treated groups C (mean grade 3.24; range 3.05-3.45) and D (2.69, range 2.4-2.9) presented statistically significant better results (lower grades) compared with the untreated group B. Group D had significantly better results (lower grades) than group C.

conclusionsThe intraperitoneal injection of erythropoietin and sildenafil protects against ischemia/reperfusion injury after testicular torsion and detorsion. Sildenafil may have a stronger action than erythropoietin at the doses used in this study.

Indexed as

AnimalsErythropoietinInjections, IntraperitonealMalePhosphodiesterase 5 InhibitorsPiperazinesPurinesRats, WistarReperfusion InjurySildenafil CitrateSpermatic Cord TorsionSulfonesTestisErythropoietinPhosphodiesterase 5 InhibitorsPiperazinesPurinesSildenafil CitrateSulfones

Identifiers

PMID24097275
OpenAlexW2100698386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.