ArticleInflammatory bowel diseases2013
Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.
Article in Inflammatory bowel diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Development of an APC and TP53-based duplex sequencing assay to positively predict colorectal cancer response to anti-EGFR therapy.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- The Role of Biomarkers in Surveillance of Ulcerative Colitis-Associated Colorectal Cancer: A Scoping Review.Journal of clinical medicine · 2025Review
- Article
- Colonic Mucosal Gene Expression Profile in Patients with Neoplastic Progression in Longstanding Ulcerative Colitis.Clinical and experimental gastroenterology · 2025Article
- Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis.medRxiv : the preprint server for health sciences · 2024Article
- Review
- Telomere dysfunction in some pediatric congenital and growth-related diseases.Frontiers in pediatrics · 2023Review
- PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Predicting Colorectal Cancer Occurrence in IBD.Cancers · 2021Review
- Role of telomere shortening in anticipation of inflammatory bowel disease.World journal of gastrointestinal pharmacology and therapeutics · 2020Article
- Cancer-Associated Mutations but No Cancer: Insights into the Early Steps of Carcinogenesis and Implications for Early Cancer Detection.Trends in cancer · 2019Review
- Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care.Digestive diseases and sciences · 2019Observational
- Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer.Molecular cancer research : MCR · 2019Article
- Sequence analysis of integrated hepatitis B virus DNA during HBeAg-seroconversion.Emerging microbes & infections · 2018Article
- Precancer in ulcerative colitis: the role of the field effect and its clinical implications.Carcinogenesis · 2018Review
- From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology.Frontiers in immunology · 2018Review
- Clonal evolution of colorectal cancer in IBD.Nature reviews. Gastroenterology & hepatology · 2017Review
- Biomarkers for colitis-associated colorectal cancer.World journal of gastroenterology · 2016Review
- TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis.International journal of molecular medicine · 2015Article
- Reduced hTERT protein levels are associated with DNA aneuploidy in the colonic mucosa of patients suffering from longstanding ulcerative colitis.International journal of molecular medicine · 2014Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPatients with ulcerative colitis (UC) are at risk of developing colorectal cancer. We have previously reported that cancer progression is associated with the presence of clonal expansions and shorter telomeres in nondysplastic mucosa. We sought to validate these findings in an independent case-control study.
methodsThis study included 33 patients with UC: 14 progressors (patients with high-grade dysplasia or cancer) and 19 nonprogressors. For each patient, a mean of 5 nondysplastic biopsies from proximal, mid, and distal colon were assessed for clonal expansions, as determined by clonal length altering mutations in polyguanine tracts, and telomere length, as measured by quantitative PCR. Both parameters were compared with individual clinicopathological characteristics.
resultsClonal expansions and shorter telomeres were more frequent in nondysplastic biopsies from UC progressors than nonprogressors, but only for patients with early-onset of UC (diagnosis at younger than 50 years of age). Late-onset progressor patients had very few or no clonal expansions and longer telomeres. A few nonprogressors exhibited clonal expansions, which were associated with older age and shorter telomeres. In progressors, clonal expansions were associated with proximity to dysplasia. The mean percentage of clonally expanded mutations distinguished early-onset progressors from nonprogressors with 100% sensitivity and 80% specificity.
conclusionsEarly-onset progressors develop cancer in a field of clonally expanded epithelium with shorter telomeres. The detection of these clones in a few random nondysplastic colon biopsies is a promising cancer biomarker in early-onset UC. Curiously, patients with late-onset UC seem to develop cancer without the involvement of such fields.
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