ReviewExperimental physiology2014
Integrative physiological and computational approaches to understand autonomic control of cerebral autoregulation.
Review in Experimental physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Cerebral Blood Flow Response During Bolus Normal Saline Infusion After Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Trial
- Trial
- A Comprehensive Review of Fluid Resuscitation Strategies in Traumatic Brain Injury.Journal of clinical medicine · 2025Review
- The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player.Pharmacological reviews · 2025Review
- Cerebral hemodynamic response to upright position in acute ischemic stroke.Frontiers in neurology · 2024Article
- Changes in neurovascular coupling with cerebral perfusion pressure indicate a link to cerebral autoregulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Application of transcranial Doppler in cerebrovascular diseases.Frontiers in aging neuroscience · 2022Review
- Dynamic effects of cholinergic blockade upon cerebral blood flow autoregulation in healthy adults.Frontiers in physiology · 2022Article
- Cerebrovascular Neuroprotection after Acute Concussion in Adolescents.Annals of neurology · 2021Article
- Fetal cerebrovascular response to maternal hyperoxygenation in congenital heart disease: effect of cardiac physiology.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Article
- One-Dimensional Statistical Parametric Mapping Identifies Impaired Orthostatic Cerebrovascular and Cardiovascular Response in Frailty Index.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The Dynamic Relationship Between Cortical Oxygenation and End-TidalFrontiers in physiology · 2021Article
- Editorial: Imaging Cerebrovascular Reactivity: Physiology, Physics and Therapy.Frontiers in physiology · 2021Article
- Control of Cerebral Blood Flow by Blood Gases.Frontiers in physiology · 2021Article
- Dynamic Cerebral Autoregulation Post Endovascular Thrombectomy in Acute Ischemic Stroke.Brain sciences · 2020Article
- Quantification of dynamic cerebral autoregulation and COJournal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke.Neuropsychiatric disease and treatment · 2020Review
- Autoregulation assessment by direct visualisation of pial arterial blood flow in the piglet brain.Scientific reports · 2019Article
- How I monitor cerebral autoregulation.Critical care (London, England) · 2019Article
- Revisiting human cerebral blood flow responses to augmented blood pressure oscillations.The Journal of physiology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The brain requires steady delivery of oxygen and glucose, without which neurodegeneration occurs within minutes. Thus, the ability of the cerebral vasculature to maintain relatively steady blood flow in the face of changing systemic pressure, i.e. cerebral autoregulation, is critical to neurophysiological health. Although the study of autoregulation dates to the early 20th century, only the recent availability of cerebral blood flow measures with high temporal resolution has allowed rapid, beat-by-beat measurements to explore the characteristics and mechanisms of autoregulation. These explorations have been further enhanced by the ability to apply sophisticated computational approaches that exploit the large amounts of data that can be acquired. These advances have led to unique insights. For example, recent studies have revealed characteristic time scales wherein cerebral autoregulation is most active, as well as specific regions wherein autonomic mechanisms are prepotent. However, given that effective cerebral autoregulation against pressure fluctuations results in relatively unchanging flow despite changing pressure, estimating the pressure-flow relationship can be limited by the error inherent in computational models of autoregulatory function. This review focuses on the autonomic neural control of the cerebral vasculature in health and disease from an integrative physiological perspective. It also provides a critical overview of the current analytical approaches to understand cerebral autoregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.