ArticleNature neuroscience2013
Origin and effect of phototransduction noise in primate cone photoreceptors.
Article in Nature neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 103 citations in OpenAlex.
- Computational-observer analysis of illumination discrimination.Journal of vision · 2019Trial
- High-Fidelity Backpropagation through Primate Foveal Cones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- An image-computable spatio-chromatic receptive field model of the midget retinal ganglion cell mosaic across the retina.Journal of computational neuroscience · 2026Article
- Directing gaze to maximize surface color information from natural scenes.Scientific reports · 2026Article
- HIGH-FIDELITY BACKPROPAGATION THROUGH PRIMATE FOVEAL CONES.bioRxiv : the preprint server for biology · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
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- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- Visual pigments underlie the sensitivity difference between day and night vision.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dark continuous noise from visual pigment as a major mechanism underlying rod-cone difference in light sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.eLife · 2024Article
- Regional tuning of photoreceptor adaptation in the primate retina.Nature communications · 2024Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.bioRxiv : the preprint server for biology · 2024Article
- Little information loss with red-green color deficient vision in natural environments.iScience · 2023Article
- Encoding of environmental illumination by primate melanopsin neurons.Science (New York, N.Y.) · 2023Article
- Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea.Cell stem cell · 2022Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Asymmetries around the visual field: From retina to cortex to behavior.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Noise in the responses of cone photoreceptors sets a fundamental limit on visual sensitivity, yet the origin of noise in mammalian cones and its relation to behavioral sensitivity are poorly understood. Our work here on primate cones improves understanding of these issues in three ways. First, we found that cone noise was not dominated by spontaneous photopigment activation or by quantal fluctuations in photon absorption, but was instead dominated by other sources, namely channel noise and fluctuations in cyclic GMP. Second, adaptation in cones, unlike that in rods, affected signal and noise differently. This difference helps to explain why thresholds for rod- and cone-mediated signals have different dependencies on background light level. Third, past estimates of noise in mammalian cones are too high to explain behavioral sensitivity. Our measurements indicate a lower level of cone noise and therefore help to reconcile physiological and behavioral estimates of cone noise and sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.