Evidence map›Paper›PMID 24096958›Full record

ReviewJournal of industrial microbiology & biotechnology2014

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.

Juan Pablo Gomez-Escribano, Mervyn J Bibb

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of industrial microbiology & biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 131 citations in OpenAlex.

  1. Synthetic and systems biotechnology · 2026
    Review
  2. Review
  3. Morphology-engineered alleviation of mycelial aggregation inSynthetic and systems biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Harnessing the microbial interactions fromSynthetic and systems biotechnology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Heterologous expression of 8-demethyl-tetracenomycin (8-dmtc) affected Streptomyces coelicolor life cycle.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021
    Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Juan Pablo Gomez-EscribanoDepartment of Molecular Microbiology, John Innes Centre, Norwich, NR4 7UH, UK, juan-pablo.gomez-escribano@jic.ac.uk.
Mervyn J Bibb
John Innes Centre · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/J/00000607Biotechnology and Biological Sciences Research Council BBS/E/J/0000A227
6 · The paper itself

Abstract

Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products.

Indexed as

Genome, BacterialBiological ProductsBiosynthetic PathwaysSecondary MetabolismStreptomyces coelicolorBiological Products

Identifiers

PMID24096958
OpenAlexW2066550363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.