ArticleParasitology research2013
Effects of dextran sulfates on the acute infection and growth stages of Toxoplasma gondii.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- The In Vitro Anti-Parasitic Activities of Emodin towardPharmaceuticals (Basel, Switzerland) · 2023Article
- Antiparasitic Effects of Sulfated Polysaccharides from Marine Hydrobionts.Marine drugs · 2021Review
- Screening of compound libraries for inhibitors of Toxoplasma growth and invasion.Parasitology research · 2020Article
- Screening of a library of traditional Chinese medicines to identify compounds and extracts which inhibit Toxoplasma gondii growth.The Journal of veterinary medical science · 2020Article
- Screening of chemical compound libraries identified new anti-Toxoplasma gondii agents.Parasitology research · 2018Article
- Modulation of host HIF-1α activity and the tryptophan pathway contributes to the anti-Biochemistry and biophysics reports · 2017Article
- Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites.PloS one · 2017Article
- Inorganic nanoparticles killInternational journal of nanomedicine · 2017Article
- Dextran sulfate inhibits acute Toxoplama gondii infection in pigs.Parasites & vectors · 2016Article
- Heparin interacts with elongation factor 1α of Cryptosporidium parvum and inhibits invasion.Scientific reports · 2015Article
- The role of carbohydrates in infection strategies of enteric pathogens.Tropical medicine and health · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasma gondii is one of the most prevalent parasites, causing toxoplasmosis in various warm-blooded animals, including humans. Because of the broad range of hosts susceptible to T. gondii, it had been postulated that a universal component of the host cell surface, such as glycosaminoglycans (GAGs), may act as a receptor for T. gondii infection. Carruthers et al. (Infect Immun 68:4005-4011, 2000) showed that soluble GAGs have also been shown to disrupt parasite binding to human fibroblasts. Therefore, we investigated the inhibitory effect of GAGs and their analogue dextran sulfate (DS) on T. gondii infection. For up to 24 h of incubation after inoculation of T. gondii, the inhibitory effect of GAGs on T. gondii infection and growth inside the host cell was weak. In contrast, DS markedly inhibited T. gondii infection. Moreover, low molecular weight DS particularly slowed the growth of T. gondii inside host cells. DS10 (dextran sulfate MW 10 kDa) was the most effective agent in these in vitro experiments and was therefore tested for its inhibitory effects in animal experiments; infection inhibition by DS10 was confirmed under these in vivo conditions. In this report, we showed that DSs, especially DS10, have the potential of a new type of drug for toxoplasmosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.