ArticleWorld journal of microbiology & biotechnology2014
Space mutagenesis of genetically engineered bacteria expressing recombinant human interferon α1b and screening of higher yielding strains.
Article in World journal of microbiology & biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Aeronautical Mutagenesis and Whole-genome Resequencing Reveal the Genetic Basis of Color Change inMycobiology · 2025Article
- Space exposure enhanced pectin-degrading enzymes expression and activity in Aspergillus costaricaensis.World journal of microbiology & biotechnology · 2023Article
- Aerospace Technology Improves Fermentation Potential of Microorganisms.Frontiers in microbiology · 2022Review
- Comparative analysis of aroma components and quality ofFrontiers in microbiology · 2022Article
- Fungal Spores Viability on the International Space Station.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2016Article
- Overexpressing target helper genes enhances secretion and glycosylation of recombinant proteins in Pichia pastoris under simulated microgravity.Journal of industrial microbiology & biotechnology · 2016Article
- A plate method for rapid screening of Ketogulonicigenium vulgare mutants for enhanced 2-keto-l-gulonic acid production.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the space mutagenesis of genetically engineered bacteria expressing recombinant human interferon α1b. The genetically engineered bacteria expressing the recombinant interferon α1b were sent into outer space on the Chinese Shenzhou VIII spacecraft. After the 17 day space flight, mutant strains that highly expressed the target gene were identified. After a series of screening of spaceflight-treated bacteria and the quantitative comparison of the mutant strains and original strain, we found five strains that showed a significantly higher production of target proteins, compared with the original strain. Our results support the notion that the outer space environment has unique effects on the mutation breeding of microorganisms, including genetically engineered strains. Mutant strains that highly express the target protein could be obtained through spaceflight-induced mutagenesis.
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